Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/27177
ชื่อเรื่อง: External validation of ACUITY/HORIZON bleeding risk score among acute coronary syndrome patients in Thai PCI Registry
ผู้แต่ง: Roongsangmanoon W.
Chichareon P.
Angkananard T.
Suwannasom P.
Chandavimol M.
Limpijankit T.
Srimahachota S.
Athisakul S.
Hutayanon P.
Kiatchoosakun S.
Thanakitcharu P.
Charoenpanichsunti M.
Chamsaard P.
Siriyotha S.
Thakkinstian A.
Sansanayudh N.
Keywords: ACUITY/HORIZON risk score
acute coronary syndrome
in-hospital major bleeding
percutaneous coronary intervention
วันที่เผยแพร่: 2022
สำนักพิมพ์: Georg Thieme Verlag
บทคัดย่อ: Background: External validation is essential before implementing a predictive model in clinical practice. This analysis validated the performance of the ACUITY/HORIZON risk score in the most contemporary Thai PCI registry. Methods: The ACUITY/HORIZON model was applied and validated externally in 12,268 ACS (acute coronary syndrome) patients. For revision and updating models, the regression coefficient of all predictors were re-estimated and then additional predictors were stepwise selected from multivariate analysis. Results: In-hospital bleeding defined by the BARC (Bleeding Academic Research Consortium) criteria was 1.3% (161 patients) and 2.3% (285 patients) by the ACUITY criteria. The calibration of both scales demonstrated overestimation of the original model with C-statistic values of 0.704 for ACUITY major bleeding and 0.793 for BARC 3 or 5 bleeding. For ACUITY major bleeding, the discriminatory power of update model improved substantially when congestive heart failure (CHF), prior vascular disease as well as body mass index (BMI) were considered. The update model demonstrated good calibration and C-statistic of 0.747 and 0.745 with no white blood cell (WBC) count. For BARC 3 or 5 bleeding, good calibration and discriminatory capacity could be observed when CHF and prior vascular disease were added in the update models, with an excellent C-statistic of 0.838 and a lower C-statistic value of 0.835 was obtained in the absence of WBC count. Conclusions: The ACUITY/HORIZON score was successfully validated in contemporary predictive and risk-adjustment models for PCI-related bleeding. The update models had good operating characteristics in patients from a real-world ACS population irrespective of bleeding definitions. © 2022 Georg Thieme Verlag. All rights reserved.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85142309738&doi=10.1055%2fa-1964-8247&partnerID=40&md5=e15413223bd7468231575157f4b5d801
https://ir.swu.ac.th/jspui/handle/123456789/27177
ISSN: 3406245
Appears in Collections:Scopus 2022

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