Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/27111
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dc.contributor.authorLam-Ubol A.
dc.contributor.authorPhattarataratip E.
dc.date.accessioned2022-12-14T03:16:54Z-
dc.date.available2022-12-14T03:16:54Z-
dc.date.issued2022
dc.identifier.issn20452322
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85137209218&doi=10.1038%2fs41598-022-19174-9&partnerID=40&md5=28ac29bffba8dd4bfc1710059c37773c
dc.identifier.urihttps://ir.swu.ac.th/jspui/handle/123456789/27111-
dc.description.abstractPost-translational modification of histones is the crucial event that affect many tumor-specific traits. A diverse type of histone modifications had been reported in different cancers with prognostic implications. This study aimed to examine the degree of histone H3 modifications in salivary gland neoplasms and their associations with tumor pathologic characteristics and proliferative activity. The expression of H3K9Ac, H3K18Ac, H3K9Me3 and Ki-67 in 70 specimens of salivary gland neoplasms, consisting of 30 mucoepidermoid carcinoma (MEC), 20 adenoid cystic carcinoma (ACC) and 20 pleomorphic adenoma (PA), were investigated immunohistochemically. The immunohistochemical scoring of 3 histone modification types and Ki-67 labeling index were determined. Overall, MEC demonstrated elevated H3K9Ac level compared with benign PA. Increased H3K9Me3 in MEC was positively correlated with small nest invasion at tumor front, advanced pathologic grade, and elevated proliferative index. In addition, the significant upregulation of all 3 types of histone H3 modification was noted in solid subtype of ACC and associated with increased cell proliferation. This study indicates that salivary gland neoplasms differentially acquire distinct patterns of histone H3 modification, which impact prognostically relevant cancer phenotypes. The hyperacetylation and methylation of histone H3 could be underpinning the prognostically worsen solid type of ACC, and the trimethylation of H3K9 may be involved in aggressive characteristics of MEC. © 2022, The Author(s).
dc.languageen
dc.publisherNature Research
dc.titleDistinct histone H3 modification profiles correlate with aggressive characteristics of salivary gland neoplasms
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationApplied Science and Engineering Progress. Vol 15, No.3 (2022)
dc.identifier.doi10.1038/s41598-022-19174-9
Appears in Collections:Scopus 2022

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