Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/17573
ชื่อเรื่อง: Biopolymer hydrogel scaffolds containing doxorubicin as a localized drug delivery system for inhibiting lung cancer cell proliferation
ผู้แต่ง: Chittasupho C.
Angklomklew J.
Thongnopkoon T.
Senavongse W.
Jantrawut P.
Ruksiriwanich W.
Keywords: Biological organs
Biomolecules
Biopolymers
Cell culture
Cell proliferation
Cellulose
Controlled drug delivery
Efficiency
Hydrogels
Scaffolds (biology)
Scanning electron microscopy
Sodium
Targeted drug delivery
A549 cells
Doxorubicin
Drug-delivery systems
Encapsulation efficiency
Freeze drying
Gelatin
Hydrogel scaffolds
Localised
Lung cancer cells
Sodium carboxymethyl cellulose
Pore size
Cellulose
Efficiency
Freeze Drying
Gelatin
Scanning Electron Microscopy
Sodium
วันที่เผยแพร่: 2021
บทคัดย่อ: A hydrogel scaffold is a localized drug delivery system that can maintain the therapeutic level of drug concentration at the tumor site. In this study, the biopolymer hydrogel scaffold encapsulating doxorubicin was fabricated from gelatin, sodium carboxymethyl cellulose, and gelatin/sodium carboxymethyl cellulose mixture using a lyophilization technique. The effects of a crosslinker on scaffold morphology and pore size were determined using scanning electron microscopy. The encapsulation efficiency and the release profile of doxorubicin from the hydrogel scaffolds were determined using UV-Vis spectrophotometry. The anti-proliferative effect of the scaffolds against the lung cancer cell line was investigated using an MTT assay. The results showed that scaffolds made from different types of natural polymer had different pore configurations and pore sizes. All scaffolds had high encapsulation efficiency and drug-controlled release profiles. The viability and proliferation of A549 cells, treated with gelatin, gelatin/SCMC, and SCMC scaffolds containing doxorubicin significantly decreased compared with control. These hydrogel scaffolds might provide a promising approach for developing a superior localized drug delivery system to kill lung cancer cells. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
URI: https://ir.swu.ac.th/jspui/handle/123456789/17573
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118320818&doi=10.3390%2fpolym13203580&partnerID=40&md5=2d077d8f4d9dacd1bb9e0cc2d84899e9
ISSN: 20734360
Appears in Collections:Scopus 1983-2021

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