Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/17559
ชื่อเรื่อง: Anti-inflammatory and anti-proliferative activities of chemical constituents from fungus Biscogniauxia whalleyi SWUF13-085
ผู้แต่ง: Jantaharn P.
Mongkolthanaruk W.
Suwannasai N.
Senawong T.
Tontapha S.
Amornkitbumrung V.
Boonmak J.
Youngme S.
McCloskey S.
วันที่เผยแพร่: 2021
บทคัดย่อ: The fungus Biscogniauxia whalleyi SWUF13-085 from the Graphostomataceae family was studied for potential anti-inflammatory and anticancer agents. A diverse array of natural products was identified. Six of which were undescribed compounds, including xylariterpenoids L-N, (1R,2S,6R,7S)-1,2-dihydroxy-α-bisabolol, 6-[(1R)-1-hydroxy-1-methyl-2-propenyl]-4-methoxy-3-methyl-2H-pyran-2-one and (1R*,4S*,5S*,7S*,10R*)-guaia-11 (12)-en-7,10-diol. Several of the isolated compounds such as bergamotene, guaiane and phthalide derivatives showed activity in both the inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells with IC50 values in the range of 2.48–10.82 μg/mL and anti-proliferation against HeLa cells with IC50 values in the range of 8.64–31.16 μg/mL. While compounds such as cerebrosides A and C only exhibited inhibitory effects on NO production with IC50 values in the range of 4.45–10.28 μg/mL. © 2021 Elsevier Ltd
URI: https://ir.swu.ac.th/jspui/handle/123456789/17559
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112231354&doi=10.1016%2fj.phytochem.2021.112908&partnerID=40&md5=63a3c474ef6983e94030cb1f2181d68b
ISSN: 319422
Appears in Collections:Scopus 1983-2021

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