Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/17539
ชื่อเรื่อง: Anti-inflammatory and cytotoxic agents from Xylaria sp. SWUF09-62 fungus
ผู้แต่ง: Patjana T.
Jantaharn P.
Katrun P.
Mongkolthanaruk W.
Suwannasai N.
Senawong T.
Tontapha S.
Amornkitbumrung V.
McCloskey S.
Keywords: 3,4 dihydro 5,7,8 trihydroxy 3 methylisocoumarin
3,4 dihydro 8 hydroxy 7 methoxy 3 methylisocoumarin
6 ethyl 7,8 dihydroxy 4h chromen 4 one
6 ethyl 8 hydroxy 4h chromen 4 one
antiinflammatory agent
cytotoxic agent
diclofenac
nitric oxide
unclassified drug
antiinflammatory agent
antineoplastic agent
biological product
lipopolysaccharide
antiinflammatory activity
Article
cancer cell
carbon nuclear magnetic resonance
cell viability
chemical structure
chemoprophylaxis
controlled study
cytotoxicity
fungus
IC50
infrared spectroscopy
macrophage
mass spectrometry
MTT assay
nonhuman
nuclear magnetic resonance
Xylariales
animal
chemistry
HCT 116 cell line
HT-29 cell line
human
metabolism
mouse
nuclear magnetic resonance spectroscopy
preclinical study
RAW 264.7 cell line
Animals
Anti-Inflammatory Agents
Antineoplastic Agents
Biological Products
Drug Evaluation, Preclinical
HCT116 Cells
HT29 Cells
Humans
Lipopolysaccharides
Magnetic Resonance Spectroscopy
Mice
Molecular Structure
Nitric Oxide
RAW 264.7 Cells
Xylariales
วันที่เผยแพร่: 2021
บทคัดย่อ: The ongoing search for anti-cancer agents from microorganisms led to the isolation of four new compounds including 6-ethyl-8-hydroxy-4H-chromen-4-one (1), 6-ethyl-7,8-dihydroxy-4H-chromen-4-one (2), (3S)-3,4-dihydro-8-hydroxy-7-methoxy-3-methylisocoumarin (3) and (3S)-3,4-dihydro-5,7,8-trihydroxy-3-methylisocoumarin (4), together with eleven known compounds (5–15) from Xylaria sp. SWUF09-62 fungus. The chemical structures were deduced from IR, 1D and 2D NMR, and MS data. The absolute configurations of 3 and 4 were determined by ECD experiment. Compounds 2 and 4 indicated possible chemo-prevention and chemo-therapeutic properties, exhibited anti-inflammatory properties by reducing nitric oxide production in LPS-stimulated RAW264.7 cells (IC50 = 1.57 ± 0.25 and 3.02 ± 0.27 μg/mL) and cytotoxicity against HT29 cells (IC50 = 16.46 ± 0.48 and 97.78 ± 7.14 μg/mL). © 2019 Informa UK Limited, trading as Taylor & Francis Group.
URI: https://ir.swu.ac.th/jspui/handle/123456789/17539
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85071024282&doi=10.1080%2f14786419.2019.1652292&partnerID=40&md5=38a2f447c8d906b70394b5545a002d26
ISSN: 14786419
Appears in Collections:Scopus 1983-2021

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