Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/17506
ชื่อเรื่อง: Chemical composition of essential oil from piper sarmentosum fruit and neuroprotective activity
ผู้แต่ง: Athikomkulchai S.
Loyfar P.
Jira-Arnon R.
Tadtong S.
Sareedenchai V.
Phattanaphakdee W.
Ruangrungsi N.
Chittasupho C.
Keywords: caryophyllene
copaene
elemicin
essential oil
myristicin
neuroprotective agent
piper sarmentosum extract
plant extract
quercetin
thymol
unclassified drug
animal cell
antiinflammatory activity
apoptosis
Article
cell viability
controlled study
degenerative disease
distillation
drug analysis
embryoid body
endoplasmic reticulum stress
fruit
gas chromatography
high performance liquid chromatography
hydrodistillation
IC50
low drug dose
mass spectrometry
MTT assay
nerve cell
neurite outgrowth
neuritogenic activity
neuroprotection
nonhuman
nutmeg
oxidative stress
pharmacology
Piper sarmentosum
rosemary
spinal ganglion
XTT assay
วันที่เผยแพร่: 2021
บทคัดย่อ: A number of complementary medicines have been investigated for their neuroprotection and treatment of neurodegenerative diseases. This study aimed to analyze the chemical compounds and the neuroprotective activity Piper sarmentosum Roxb. fruit essential oil. The essential oil from the fruits of P. sarmentosum (Piperaceae) was extracted by hydrodistillation. Chemical components of the oil were analyzed by Gas chromatography-Mass spectrometry (GC-MS). The effects of essential oil from P. sarmentosum fruit on P19-derived neuron cell viability, neuron length, and branching numbers were investigated. The results showed that the yield of essential oil obtained from P. sarmentosum fruit distillation was 1.47% w/w. The essential oil from P. sarmentosum fruit contained major compounds, namely; myristicin (88.9%), E-caryophyllene (3.7%), elemicin (1.4%), pentadecane (1.0%), apiole (1.0%), α-copaene (0.7%), and β-copaene (0.2%). The essential oil at 1 and 10 ng/mL significantly increased cell viability, elongated neuron length, and enhanced branching numbers. Therefore, it was suggested that the oil extracted from P. sarmentosum fruit may have promising neuroprotective and neuritogenic effects on neurons and prevent neurodegenerative diseases. © 2021 Athikomkulchai et al.
URI: https://ir.swu.ac.th/jspui/handle/123456789/17506
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102560249&doi=10.26538%2ftjnpr%2fv5i2.18&partnerID=40&md5=4d2d77a2a09669848885af0ddb881af9
ISSN: 26160684
Appears in Collections:Scopus 1983-2021

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