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dc.contributor.authorAngkananard T.
dc.contributor.authorInthanoo T.
dc.contributor.authorSricholwattana S.
dc.contributor.authorRattanajaruskul N.
dc.contributor.authorWongsoasu A.
dc.contributor.authorRoongsangmanoon W.
dc.description.abstractIntroduction. The inflammatory response plays a potential role for the pathogenesis and adverse outcomes of heart failure (HF). We aimed to explore the predictive role of baseline neutrophil-to-lymphocyte ratio (NLR) and mean platelet volume-to-lymphocyte ratio (MPVLR) on cardiovascular events (CVEs) in patients hospitalized with acute HF. Materials and Methods. A retrospective cohort study was conducted in 321 patients with HF between January 2017 and December 2019. The association between their NLR, MPVLR, and combined NLR and MPVLR and CVEs, rehospitalization for HF, in-hospital death, and a composite outcome was explored by survival analysis using a Cox proportional hazard model. They were separately investigated and compared with the area under the receiver operating characteristics curve (AUC). Results. Up to the end of the 3-year follow-up, 96 (29.9%) had CVEs, 106 (33.0%) died, 62 (19.3%) were rehospitalized with HF, and 21 (6.5%) died during admission. The NLR and MPVLR were significantly associated with CVEs (adjusted HR for NLR≥3.29, 3.11; 95% CI, 1.98-4.89; MPVLR≥8.57, 2.86; 95% CI, 1.87-4.39), readmissions for HF (adjusted HR for NLR≥3.58, 2.70; 95% CI, 1.58-4.61; MPVLR≥6.43, 2.84; 95% CI,1.59-5.07), in-hospital mortality (adjusted HR for NLR≥3.29, 9.54; 95% CI, 2.19-41.40; MPVLR≥8.57, 7.87; 95% CI, 2.56-24.19), and composite outcome (adjusted HR for NLR≥3.32, 4.76; 95% CI, 3.29-6.89; MPVLR≥7.07, 3.64; 95% CI, 2.58-5.15). The AUC of NLR and MPVLR for CVEs were 0.67 (95% CI, 0.61-0.72) and 0.63 (95% CI, 0.58-0.69). Combined NLR and MPVLR increased the AUC to 0.77 (95% CI, 0.72-0.83) with statistical significance. Conclusion. The elevated NLR and MPVLR on admission in patients with acute HF were independently associated with worse CVEs, rehospitalization for HF, in-hospital death, and composite outcomes. These economical biomarkers should be considered in the management and follow-up care of patients with acute HF. © 2021 Teeranan Angkananard et al.
dc.subjectacetylsalicylic acid
dc.subjectbeta adrenergic receptor blocking agent
dc.subjectdipeptidyl carboxypeptidase inhibitor
dc.subjectdiuretic agent
dc.subjecthydroxymethylglutaryl coenzyme A reductase inhibitor
dc.subjectpurinergic P2Y receptor antagonist
dc.subjectabsolute lymphocyte count
dc.subjectacute heart failure
dc.subjectblood cell ratio
dc.subjectbody mass
dc.subjectcohort analysis
dc.subjectcontrolled study
dc.subjectdiabetes mellitus
dc.subjectelectronic medical record
dc.subjectfollow up
dc.subjectheart left ventricle ejection fraction
dc.subjecthospital readmission
dc.subjectin-hospital mortality
dc.subjectmajor clinical study
dc.subjectmean platelet volume to lymphocyte ratio
dc.subjectneutrophil lymphocyte ratio
dc.subjectNew York Heart Association class
dc.subjectpredictive value
dc.subjectpulse rate
dc.subjectretrospective study
dc.subjectsensitivity and specificity
dc.subjectsurvival analysis
dc.subjecttransthoracic echocardiography
dc.titleThe Predictive role of Neutrophil-to-Lymphocyte Ratio (NLR) and Mean Platelet Volume-to-Lymphocyte Ratio (MPVLR) for Cardiovascular Events in Adult Patients with Acute Heart Failure
dc.identifier.bibliograpycitationMediators of Inflammation. Vol 2021, No. (2021)
Appears in Collections:Scopus 1983-2021

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