Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/17303
ชื่อเรื่อง: Biocompatibility study of modified injectable hyaluronic acid hydrogel with mannitol/BSA to alveolar bone cells
ผู้แต่ง: Areevijit K.
Dhanesuan N.
Luckanagul J.A.
Rungsiyanont S.
Keywords: Biocompatibility
Bone
Cell culture
Collagen
Controlled drug delivery
Hyaluronic acid
Hydrogels
Morphology
Organic acids
Phosphatases
Polyols
ALkaline phosphatase
Alkaline phosphatase activity
Bone grafting materials
Drug delivery materials
Encapsulated cell
Hyaluronic acid hydrogels
Immunohistochemistry
Methacrylated hyaluronic acids
Cells
alkaline phosphatase
collagen type 1
hyaluronic acid derivative
hydrogel
mannitol
biomaterial
bovine serum albumin
hyaluronic acid
mannitol
alveolar bone
Article
biocompatibility
bone cell
cell culture
cell encapsulation
cell metabolism
cell shape
cell structure
cell viability
controlled study
enzyme assay
human
human cell
immunohistochemistry
priority journal
protein expression
protein synthesis
adult
animal
bone
bone development
bovine
cell differentiation
cell survival
chemistry
cytology
drug effect
hydrogel
metabolism
middle aged
pharmacology
Adult
Animals
Biocompatible Materials
Bone and Bones
Cattle
Cell Differentiation
Cell Survival
Cells, Cultured
Humans
Hyaluronic Acid
Hydrogels
Mannitol
Middle Aged
Osteogenesis
Serum Albumin, Bovine
วันที่เผยแพร่: 2021
บทคัดย่อ: The quality and quantity of bone are crucial to the success of dental implant treatment. Recently, bone grafting materials have reached some limitations. This study aimed to evaluate the biocompatibility of novel drug delivery material, injectable methacrylated hyaluronic acid hydrogel incorporated with different ratios of mannitol and BSA (Man/BSA MeHA), to human alveolar bone cells. The three-dimensionally encapsulated cell culture was evaluated with the resazurin cell viability test, alkaline phosphatase activity assay, immunohistochemistry test for collagen type-I synthesis, and cell morphology. The results showed that the encapsulated cells were viable in all four ratios of Man/BSA MeHA hydrogel and the average metabolic rate was not less than the control group. The morphology test showed round shape cells at the upper portion of the hydrogel and fibroblast-like or polygonal shape at the lower portion of hydrogel next to the culture plate. All four groups could express enzyme alkaline phosphatase and collagen type-I. In conclusion, four ratios of Man/BSA MeHA hydrogel were biocompatible with primary human alveolar bone cells. © The Author(s) 2020.
URI: https://ir.swu.ac.th/jspui/handle/123456789/17303
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85095454840&doi=10.1177%2f0885328220971746&partnerID=40&md5=2c3dda4633f7083059ba6a4516713502
ISSN: 8853282
Appears in Collections:Scopus 1983-2021

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