Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/17227
Title: The burden of norovirus disease in children: a multi-country study in Chile, Brazil, Thailand and the Philippines
Authors: Safadi M.A.
Riera-Montes M.
Bravo L.
Tangsathapornpong A.
Lagos R.
Thisyakorn U.
Linhares A.C.
Capeding R.
Prommalikit O.
Verstraeten T.
O'Ryan M.
Keywords: acute gastroenteritis
Article
asymptomatic infection
Brazil
child
Chile
clinical feature
cohort analysis
coinfection
community acquired infection
disease burden
disease severity assessment
female
global disease burden
hospital infection
hospital patient
human
incidence
major clinical study
male
molecular epidemiology
nonhuman
Norovirus
Norovirus genotype GII.4
norovirus infection
observational study
outpatient
Philippines
prevalence
prospective study
Rotavirus infection
Thailand
calicivirus infection
feces
genetics
genotype
infant
Norovirus
virus RNA
Brazil
Caliciviridae Infections
Child
Chile
Feces
Genotype
Humans
Infant
Norovirus
Philippines
Prospective Studies
RNA, Viral
Thailand
Issue Date: 2021
Abstract: Background: Noroviruses (NoVs) cause acute gastroenteritis (AGE) worldwide, affecting children in particular. We aimed to estimate the burden of disease due to NoV among children aged <6 years in Brazil, Chile, Philippines and Thailand. Methods: This was a prospective, hospital-based, observational study. Children were recruited over one year between 2014 and 2017. Four cohorts were analysed: community-acquired AGE outpatients and inpatients, nosocomial AGE inpatients, and asymptomatic outpatients. We collected demographic and clinical data, and a stool sample that was tested for NoV. Positive samples were tested for Rotavirus (RV) and NoV-genotyped. Disease severity was assessed by the Vesikari and modified Vesikari scores. Prevalence and incidence of NoV-AGE were estimated by cohort and country. Results: 1637 participants yielded valid laboratory results. The proportion of NoV-positive cases was 23.8% (95% CI 20.8-27.2) in the outpatient cohort, 17.9% (15.0-21.3) in the hospital cohort, 21.4% (12.7-33.8) in the nosocomial cohort and 9.6% (6.9-13.2) in the asymptomatic cohort. Genotype GII.4 was predominant (58%). Less than 4% samples had RV coinfection. In general, NoV-positive subjects had more severe presentations than NoV-negative subjects. Conclusions: NoV caused AGE with substantial burden throughout the studied settings, with higher relative frequency in Brazil where RV vaccination coverage is high. © 2021 The Authors
URI: https://ir.swu.ac.th/jspui/handle/123456789/17227
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110538928&doi=10.1016%2fj.ijid.2021.06.037&partnerID=40&md5=1eef88423a611972c45696414f28644e
ISSN: 12019712
Appears in Collections:Scopus 1983-2021

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