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Title: | The burden of norovirus disease in children: a multi-country study in Chile, Brazil, Thailand and the Philippines |
Authors: | Safadi M.A. Riera-Montes M. Bravo L. Tangsathapornpong A. Lagos R. Thisyakorn U. Linhares A.C. Capeding R. Prommalikit O. Verstraeten T. O'Ryan M. |
Keywords: | acute gastroenteritis Article asymptomatic infection Brazil child Chile clinical feature cohort analysis coinfection community acquired infection disease burden disease severity assessment female global disease burden hospital infection hospital patient human incidence major clinical study male molecular epidemiology nonhuman Norovirus Norovirus genotype GII.4 norovirus infection observational study outpatient Philippines prevalence prospective study Rotavirus infection Thailand calicivirus infection feces genetics genotype infant Norovirus virus RNA Brazil Caliciviridae Infections Child Chile Feces Genotype Humans Infant Norovirus Philippines Prospective Studies RNA, Viral Thailand |
Issue Date: | 2021 |
Abstract: | Background: Noroviruses (NoVs) cause acute gastroenteritis (AGE) worldwide, affecting children in particular. We aimed to estimate the burden of disease due to NoV among children aged <6 years in Brazil, Chile, Philippines and Thailand. Methods: This was a prospective, hospital-based, observational study. Children were recruited over one year between 2014 and 2017. Four cohorts were analysed: community-acquired AGE outpatients and inpatients, nosocomial AGE inpatients, and asymptomatic outpatients. We collected demographic and clinical data, and a stool sample that was tested for NoV. Positive samples were tested for Rotavirus (RV) and NoV-genotyped. Disease severity was assessed by the Vesikari and modified Vesikari scores. Prevalence and incidence of NoV-AGE were estimated by cohort and country. Results: 1637 participants yielded valid laboratory results. The proportion of NoV-positive cases was 23.8% (95% CI 20.8-27.2) in the outpatient cohort, 17.9% (15.0-21.3) in the hospital cohort, 21.4% (12.7-33.8) in the nosocomial cohort and 9.6% (6.9-13.2) in the asymptomatic cohort. Genotype GII.4 was predominant (58%). Less than 4% samples had RV coinfection. In general, NoV-positive subjects had more severe presentations than NoV-negative subjects. Conclusions: NoV caused AGE with substantial burden throughout the studied settings, with higher relative frequency in Brazil where RV vaccination coverage is high. © 2021 The Authors |
URI: | https://ir.swu.ac.th/jspui/handle/123456789/17227 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110538928&doi=10.1016%2fj.ijid.2021.06.037&partnerID=40&md5=1eef88423a611972c45696414f28644e |
ISSN: | 12019712 |
Appears in Collections: | Scopus 1983-2021 |
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