Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/17170
ชื่อเรื่อง: Expression of cathepsin B and cystatin A in oral lichen planus
ผู้แต่ง: Bangsuwan P.
Hirunwidchayarat W.
Jirawechwongsakul P.
Talungchit S.
Taebunpakul P.
วันที่เผยแพร่: 2021
บทคัดย่อ: Objective: Cathepsin B (Cat-B), a cysteine protease, and cystatin A (Cys-A), a protease inhibitor, are involved in the immune response. This study determined Cat-B and Cys-A expression in oral lichen planus (OLP) by immunohistochemistry. Materials and Methods: Thirty specimens each of OLP and healthy gingiva (HG) were included. The expression pattern, the number of positive cells, the staining intensity, and the immunoreactive score (IRS) of Cat-B and Cys-A were investigated. The data were analyzed by using unpaired t-test, Chi-square, and Spearman's rank correlation. Results: The Cat-B expression in OLP was observed as cytoplasmic staining in the epithelial cells, whereas Cys-A expression was exhibited in the nucleus and cytoplasm of the epithelium. An increase in Cat-B staining intensity was also observed in the basal cells. Conversely, the high staining intensity of Cys-A was observed in the stratum spinosum, but not the stratum basale. In HG, Cat-B expression demonstrated a relatively consistent intensity in the epithelial layer. The Cys-A expression in HG was similar to OLP with a lower staining intensity. The mean percentage of positive cells and the IRS score of Cat-B and Cys-A in OLP were significantly higher than HG (P 0.05). There was no correlation between Cat-B and Cys-A levels in OLP. Interestingly, Cat-B expression in erosive OLP was greater than in non-erosive OLP (P 0.05). Conclusion: The Cat-B and Cys-A expression in OLP was more outstanding than in HG, suggesting possible roles for the process of OLP pathogenesis. In addition, Cat-B expression may be an indicator of the disease severity. © 2021 Journal of the Anatomical Society of India. All rights reserved.
URI: https://ir.swu.ac.th/jspui/handle/123456789/17170
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116293298&doi=10.4103%2fjispcd.JISPCD_97_21&partnerID=40&md5=d73010c3161325e9f2d24f1b09e1eb30
ISSN: 22310762
Appears in Collections:Scopus 1983-2021

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