Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/15447
ชื่อเรื่อง: Atypical manifestation of progressive outer retinal necrosis in AIDS patient with CD4+ T-cell counts more than 100 cells/microL on highly active antiretroviral therapy.
ผู้แต่ง: Vichitvejpaisal P.
Reeponmahar S.
Tantisiriwat W.
Keywords: aciclovir
antivirus agent
ganciclovir
acquired immune deficiency syndrome
adult
article
case report
CD4 lymphocyte count
chemically induced disorder
female
highly active antiretroviral therapy
human
necrosis
polymerase chain reaction
retina
retina disease
Thailand
Varicella zoster virus
virology
Acquired Immunodeficiency Syndrome
Acyclovir
Adult
Antiretroviral Therapy, Highly Active
Antiviral Agents
CD4 Lymphocyte Count
Female
Ganciclovir
Herpesvirus 3, Human
Humans
Necrosis
Polymerase Chain Reaction
Retina
Retinal Diseases
Thailand
วันที่เผยแพร่: 2009
บทคัดย่อ: Typical progressive outer retinal necrosis (PORN) is an acute ocular infectious disease in acquired immunodeficiency syndrome (AIDS) patients with extremely low CD4+ T-cell counts. It is a form of the Varicella- zoster virus (VZV) infection. This destructive infection has an extremely rapid course that may lead to blindness in affected eyes within days or weeks. Attempts at its treatment have had limited success. We describe the case of a bilateral PORN in an AIDS patient with an initial CD4+ T-cell count >100 cells/microL that developed after initiation of highly active antiretroviral therapy (HAART). A 29-year-old Thai female initially diagnosed with human immunodeficiency virus (HIV) in 1998, presented with bilaterally decreased visual acuity after initiating HAART two months earlier. Multiple yellowish spots appeared in the deep retina without evidence of intraocular inflammation or retinal vasculitis. Her CD4+ T-cell count was 127 cells/microL. She was diagnosed as having PORN based on clinical features and positive VZV in the aqueous humor and vitreous by polymerase chain reaction (PCR). Despite combined treatment with intravenous acyclovir and intravitreous ganciclovir, the patient's visual acuity worsened with no light-perception in either eye. This case suggests that PORN should be included in the differential diagnosis of reduced visual acuity in AIDS patients initiating HAART with higher CD4+ T-cell counts. PORN may be a manifestation of the immune reconstitution syndrome.
URI: https://ir.swu.ac.th/jspui/handle/123456789/15447
https://www.scopus.com/inward/record.uri?eid=2-s2.0-77957320060&partnerID=40&md5=c8cba218d1c8e43790279086ab037e9a
ISSN: 1252208
Appears in Collections:Scopus 1983-2021

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