Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/15315
ชื่อเรื่อง: The use of the stabilization period in electroconvulsive therapy research in schizophrenia : II. Implementation
ผู้แต่ง: Chanpattana W.
Kirdcharoen N.
Techakasem P.
Chakrabhand M.L.S.
Tuntirungsee Y.
Prasertsuk Y.
Keywords: adolescent
adult
article
clinical protocol
clinical trial
controlled clinical trial
controlled study
electroconvulsive therapy
female
human
male
methodology
middle aged
multimodality cancer therapy
phase 1 clinical trial
phase 2 clinical trial
prospective study
randomized controlled trial
schizophrenia
single blind procedure
standard
treatment outcome
Adolescent
Adult
Clinical Protocols
Combined Modality Therapy
Electroconvulsive Therapy
Female
Humans
Male
Middle Aged
Prospective Studies
Schizophrenia
Single-Blind Method
Treatment Outcome
วันที่เผยแพร่: 1999
บทคัดย่อ: Background: Electroconvulsive therapy (ECT) has been used to treat schizophrenia since its inception in 1938. Nonetheless, there has never been a research study documenting the efficacy of ECT in schizophrenia. All ECT studies suffered unexceptable methodological flaws. The authors hypothesized the 3-week stabilization period as: 1) a screening method for ECT responders, 2) a procedure for obtaining a homogeneous group of patients ideally suitable for the continuation treatment study, and, 3) as a part of our relapse criteria. Method: One hundred and fourteen schizophrenic patients received acute Phase I treatment with bilateral ECT and flupenthixol (12-24 mg/d). After the first sign of clinical improvement, all patients had to pass a 3-week stabilization period during which their clinical improvement had to be sustained. The patients had to receive at least 20 ECT treatments before being considered unresponsive to ECT. Fifty one patients enrolled in the continuation (Phase II) treatment study, and were randomized to the 3 treatment groups. Results: In Phase I study, 58 patients were ECT responders by our criteria, 43 were nonresponders, and 13 were drop-outs. Forty five patients either relapsed or completed the Phase II study, while 6 patients dropped out. By our relapse criteria, 6 of 15 relapsed in the combined C-ECT and flupenthixol group, and 14 of 15 relapsed in both the group treated with C-ECT alone or flupenthixol alone. The use of the stabilization period in this study could complete all three objectives previously described. Conclusions: The use of the stabilization period is very useful in ECT research in schizophrenia.
URI: https://ir.swu.ac.th/jspui/handle/123456789/15315
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033144887&partnerID=40&md5=697be7f4529abbdfae42a7d0568fab2f
ISSN: 1252208
Appears in Collections:Scopus 1983-2021

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