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https://ir.swu.ac.th/jspui/handle/123456789/15226| Title: | Iridoids with anti-inflammatory activity from Vitex peduncularis |
| Authors: | Suksamrarn A. Kumpun S. Kirtikara K. Yingyongnarongkul B. Suksamrarn S. |
| Keywords: | agnuside antiinflammatory agent cyclooxygenase 2 iridoid pedunculariside plant extract unclassified drug Vitex peduncularis extract animal cell antiinflammatory activity article bark controlled study cytotoxicity drug isolation drug structure enzyme inhibition IC 50 nonhuman Vero cell Animals Anti-Inflammatory Agents Cercopithecus aethiops Cyclooxygenase 1 Cyclooxygenase 2 Glucosides Iridoids Isoenzymes Magnetic Resonance Spectroscopy Membrane Proteins Mice Plant Extracts Prostaglandin-Endoperoxide Synthases Pyrans Vero Cells Vitex Animalia Vitex |
| Issue Date: | 2002 |
| Abstract: | A new iridoid, pedunculariside, together with the known iridoid agnuside were isolated from the butanol extract of Vitex peduncularis stem bark. Both pedunculariside and agnuside showed preferential inhibition of COX-2, with IC50 values of 0.15 ± 0.21 mg/ml and 0.026 ± 0.015 mg/ml respectively, while having only small inhibitory effects on COX-1. Both compounds did not exhibit cytotoxicity against vero cells. |
| URI: | https://ir.swu.ac.th/jspui/handle/123456789/15226 https://www.scopus.com/inward/record.uri?eid=2-s2.0-0036154975&doi=10.1055%2fs-2002-20048&partnerID=40&md5=a1eca6bac96acee5285401d04f3939ef |
| ISSN: | 320943 |
| Appears in Collections: | Scopus 1983-2021 |
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