Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/15196
ชื่อเรื่อง: Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana
ผู้แต่ง: Suksamrarn S.
Suwannapoch N.
Phakhodee W.
Thanuhiranlert J.
Ratananukul P.
Chimnoi N.
Suksamrarn A.
Keywords: alpha mangostin
antimycobacterial agent
garcinia mangostana extract
garcinone B
mangostin
plant extract
tuberculostatic agent
unclassified drug
xanthone derivative
antiinfective agent
xanthone derivative
antibacterial activity
article
dose response
drug activity
drug effect
drug isolation
drug screening
drug structure
fruit
Garcinia mangostana
minimum inhibitory concentration
Mycobacterium
Mycobacterium tuberculosis
nonhuman
oxygenation
plant seed
prenylation
chemistry
fruit
Garcinia mangostana
isolation and purification
microbiological examination
protein processing
Anti-Bacterial Agents
Fruit
Garcinia mangostana
Microbial Sensitivity Tests
Protein Isoprenylation
Xanthones
วันที่เผยแพร่: 2003
บทคัดย่อ: Prenylated xanthones, isolated from the fruit hulls and the edible arils and seeds of Garcinia mangostana, were tested for their antituberculosis potential. α- and β-Mangostins and garcinone B exhibited strong inhibitory effect against Mycobacterium tuberculosis with the minimum inhibitory concentration (MIC) value of 6.25 μg/ml. Tri- and tetra-oxygenated xanthones with di-C5 units or with a C5 and a modified C 5 groups are essential for high activities. Substitution in the A and C rings has been shown to modify the bioactivity of the compounds. © 2003 Pharmaceutical Society of Japan.
URI: https://ir.swu.ac.th/jspui/handle/123456789/15196
https://www.scopus.com/inward/record.uri?eid=2-s2.0-1542785862&doi=10.1248%2fcpb.51.857&partnerID=40&md5=1836b88c8e26226133b204b8a5a60261
ISSN: 92363
Appears in Collections:Scopus 1983-2021

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