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https://ir.swu.ac.th/jspui/handle/123456789/15196| Title: | Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana |
| Authors: | Suksamrarn S. Suwannapoch N. Phakhodee W. Thanuhiranlert J. Ratananukul P. Chimnoi N. Suksamrarn A. |
| Keywords: | alpha mangostin antimycobacterial agent garcinia mangostana extract garcinone B mangostin plant extract tuberculostatic agent unclassified drug xanthone derivative antiinfective agent xanthone derivative antibacterial activity article dose response drug activity drug effect drug isolation drug screening drug structure fruit Garcinia mangostana minimum inhibitory concentration Mycobacterium Mycobacterium tuberculosis nonhuman oxygenation plant seed prenylation chemistry fruit Garcinia mangostana isolation and purification microbiological examination protein processing Anti-Bacterial Agents Fruit Garcinia mangostana Microbial Sensitivity Tests Protein Isoprenylation Xanthones |
| Issue Date: | 2003 |
| Abstract: | Prenylated xanthones, isolated from the fruit hulls and the edible arils and seeds of Garcinia mangostana, were tested for their antituberculosis potential. α- and β-Mangostins and garcinone B exhibited strong inhibitory effect against Mycobacterium tuberculosis with the minimum inhibitory concentration (MIC) value of 6.25 μg/ml. Tri- and tetra-oxygenated xanthones with di-C5 units or with a C5 and a modified C 5 groups are essential for high activities. Substitution in the A and C rings has been shown to modify the bioactivity of the compounds. © 2003 Pharmaceutical Society of Japan. |
| URI: | https://ir.swu.ac.th/jspui/handle/123456789/15196 https://www.scopus.com/inward/record.uri?eid=2-s2.0-1542785862&doi=10.1248%2fcpb.51.857&partnerID=40&md5=1836b88c8e26226133b204b8a5a60261 |
| ISSN: | 92363 |
| Appears in Collections: | Scopus 1983-2021 |
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