Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/15181
ชื่อเรื่อง: Acute and maintenance ECT with flupenthixol in refractory schizophrenia: Sustained improvements in psychopathology, quality of life, and social outcomes
ผู้แต่ง: Chanpattana W.
Kramer B.A.
Keywords: flupentixol
adult
clinical trial
conference paper
controlled clinical trial
controlled study
drug efficacy
electroconvulsive therapy
human
major clinical study
mental disease
mini mental state examination
outcomes research
phase 1 clinical trial
phase 2 clinical trial
priority journal
quality of life
rating scale
schizophrenia
social status
วันที่เผยแพร่: 2003
บทคัดย่อ: Objective: To determine the effects of ECT combined with antipsychotic medication therapy on psychopathology, quality of life, and social functioning in patients with refractory schizophrenia. Method: An open acute (Phase I) and maintenance (Phase II) study of the combination of ECT and flupenthixol in the treatment of 46 schizophrenic patients who were nonresponsive to antipsychotic medication from at least two different classes. Scales used: the Brief Psychiatric Rating Scale (BPRS), the Quality of Life Scale (QLS), Social and Occupational Functioning Assessment Scale (SOFAS), Global Assessment of Functioning (GAF), and Mini-Mental State Exam (MMSE). The duration of Phase II was 1 year. Results: In Phase I, there were marked reductions in the BPRS scores, and substantial increases in the QLS, SOFAS, GAF, and MMSE scores. During Phase II, the BPRS negative symptoms worsened but remained improved from baseline. Changes in other outcome measures were negligible. Conclusion: ECT and MECT combined with flupenthixol were effective in improving psychopathology in patients refractory to antipsychotic medication alone. Ratings of psychopathology, quality of life, and social functioning all improved in Phase I and were generally sustained during Phase II in patients who had remitted. © 2002 Elsevier Science B.V. All rights reserved.
URI: https://ir.swu.ac.th/jspui/handle/123456789/15181
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0042206786&doi=10.1016%2fS0920-9964%2802%2900330-4&partnerID=40&md5=6e0a871800e6bf00a52b9001abbd620a
ISSN: 9209964
Appears in Collections:Scopus 1983-2021

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