Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/15115
ชื่อเรื่อง: Effects of Pueraria mirifica on vascular function of ovariectomized rabbits.
ผู้แต่ง: Wattanapitayakul S.K.
Chularojmontri L.
Srichirat S.
Keywords: plant medicinal product
animal
article
drug effect
female
ovariectomy
pathophysiology
Pueraria
rabbit
thoracic aorta
vasoconstriction
vasodilatation
Animals
Aorta, Thoracic
Female
Ovariectomy
Plant Preparations
Pueraria
Rabbits
Vasoconstriction
Vasodilation
วันที่เผยแพร่: 2005
บทคัดย่อ: Estrogen stimulates endothelial nitric oxide (NO) production and attenuates endothelial dysfunction in ischemia/repurfusion and menopause. Recent studies have shown that phytoestrogens from dietary sources improve endothelial function and reduce cardiovascular risks. The Thai medicinal plant Pueraria mirifica (PM) contains many potent phytoestrogens including miroestrol and deoxymiroestrol but no study on vascular function has been established. Ground powder of PM was orally given to ovariectomized White New Zealand rabbits (OVX + PM group) (n = 4) weighing 3.2-4.0 kg at the dose of 100 mg/kg for 90 days. Saline-treated ovariectomized rabbits were assigned as a control group (OVX group) (n = 5). At the end of treatment thoracic aorta was isolated for functional evaluation. Maximal relaxant response to acetylcholine (ACh) was significantly increased (24%) with 3.5-fold decrease in EC50 while no change in relaxant response to sodium nitroprusside was observed Minimal and maximal responses to 17beta-estradiol (E2) were increased in the OVX + PM group and L-NAME (100 mM) attenuated Emax of E2. PM significantly decreased maximal contractile responses to norepinephrine (NE), but no change in EC50 was observed. In addition to vascular study, the authors found no significant alteration in serum cholesterol, LDL, triglyceride, HDL, ALT AST alkaline phosphatase, and lipid peroxidation in OVX + PM rabbits. These data demonstrate that PM (100 mg/kg/d) improved endothelial function through NO-dependent pathway and increased response to E2 while sensitivity to NE was reduced. In addition, it had no impact on lipid profile, liver enzymes, and ALP activities. PM is a potential source of phytoestrogens for postmenopausal women to improve cardiovascular function or reduce cardiovascular risks.
URI: https://ir.swu.ac.th/jspui/handle/123456789/15115
https://www.scopus.com/inward/record.uri?eid=2-s2.0-33748457158&partnerID=40&md5=9f1f3eece0da7463f2bc6f803e4680ec
ISSN: 1252208
Appears in Collections:Scopus 1983-2021

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