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Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/15101
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dc.contributor.authorSuksamrarn S.
dc.contributor.authorSuwannapoch N.
dc.contributor.authorAunchai N.
dc.contributor.authorKuno M.
dc.contributor.authorRatananukul P.
dc.contributor.authorHaritakun R.
dc.contributor.authorJansakul C.
dc.contributor.authorRuchirawat S.
dc.date.accessioned2021-04-05T04:32:38Z-
dc.date.available2021-04-05T04:32:38Z-
dc.date.issued2005
dc.identifier.issn404020
dc.identifier.other2-s2.0-12344255909
dc.identifier.urihttps://ir.swu.ac.th/jspui/handle/123456789/15101-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-12344255909&doi=10.1016%2fj.tet.2004.11.053&partnerID=40&md5=811e0f9e8f192f831888bf34dbc82721
dc.description.abstractBioassay-guided fractionation of the EtOAc extract of the roots of Thai Ziziphus oenoplia var. brunoniana resulted in the isolation of four new 13-membered cyclopeptide alkaloids of the 5(13) type, ziziphine N-Q. The structures of the new metabolites were elucidated on the basis of spectroscopic analyses and the stereochemical assignments were established by comparison with other related compounds of known stereochemistry. Ziziphine N and Q exhibited significant antiplasmodial activity against the parasite Plasmodium falciparum with the inhibitory concentration (IC50) values of 3.92 and 3.5 μg/mL, respectively. Ziziphine N and Q also demonstrated weak antimycobacterial activity against Mycobacterium tuberculosis with the same MIC value of 200 μg/mL. © 2004 Elsevier Ltd. All rights reserved.
dc.subjectalkaloid
dc.subjectantimalarial agent
dc.subjectantimycobacterial agent
dc.subjectcyclopeptide
dc.subjectplant extract
dc.subjectunclassified drug
dc.subjectziziphine n
dc.subjectziziphine o
dc.subjectziziphine p
dc.subjectziziphine q
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectdrug activity
dc.subjectdrug isolation
dc.subjectdrug structure
dc.subjectfractionation
dc.subjectIC 50
dc.subjectjujube
dc.subjectminimum inhibitory concentration
dc.subjectMycobacterium tuberculosis
dc.subjectnonhuman
dc.subjectplant root
dc.subjectPlasmodium falciparum
dc.subjectpriority journal
dc.subjectspectroscopy
dc.subjectstereochemistry
dc.subjectMycobacterium
dc.subjectMycobacterium tuberculosis
dc.subjectPlasmodium falciparum
dc.subjectRhamnaceae
dc.subjectZiziphus
dc.titleZiziphine N, O, P and Q, new antiplasmodial cyclopeptide alkaloids from Ziziphus oenoplia var. brunoniana
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationTetrahedron. Vol 61, No.5 (2005), p.1175-1180
dc.identifier.doi10.1016/j.tet.2004.11.053
Appears in Collections:Scopus 1983-2021

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