Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/15045
ชื่อเรื่อง: Incontinentia pigmenti achromians of Ito: An ultrastructural study
ผู้แต่ง: Palungwachira P.
Palungwachira P.
Keywords: melanin
anamnesis
article
case report
cell ultrastructure
clinical feature
dermoepidermal junction
disease course
human
hypomelanosis
hypopigmentation
incontinentia pigmenti
Ito cell
keratinocyte
Langerhans cell
male
melanosome
nonmyelinated nerve
preschool child
electron microscopy
follow up
hospitalization
immunohistochemistry
needle biopsy
pathology
pigment disorder
sensitivity and specificity
skin
ultrastructure
Biopsy, Needle
Child, Preschool
Follow-Up Studies
Humans
Immunohistochemistry
Male
Microscopy, Electron
Pigmentation Disorders
Sensitivity and Specificity
Severity of Illness Index
Skin
วันที่เผยแพร่: 2006
บทคัดย่อ: A clinico-pathological and EM study of a Thai boy with hypomelanosis of Ito, one of the neurocutaneous syndromes, is reported. At birth, typical skin hypopigmentation on the trunk and a hypopigmented streak on the left lower extremity were noted. Associated cutaneous pathology shows a decrease of melanin granules within basal and malpighian keratinocytes. Ultrastructural studies highlight a normal appearance for basal and malpighian keratinocytes, but a lack of melanosomes in the malpighian cells. Melanosomes are also dramatically reduced in the basal keratinocytes, which appear small, single or clustered and surrounded by a membrane. Melanocytic degeneration has been observed and dendritic melanocytes contained various stages of nonmelanised (stage II), partially melanised premelanosome (stage III) and rarely stage 4 melanosomes. The authors observed an increase in the number of Langerhans cell which have not previously been described. There were unmyelinated axon of nerve containing melanosomes at the dermoepidermal junction. The significance of these findings will be worthwhile to note that abnormal nerve termination in close relationship with basal keratinocyte, degenerated melanocyte, premelanosomes and langerhans cell are important in explaining the pathogenesis of Hypomelanosis of Ito.
URI: https://ir.swu.ac.th/jspui/handle/123456789/15045
https://www.scopus.com/inward/record.uri?eid=2-s2.0-33645963975&partnerID=40&md5=a600292e990bb5ddb109a1f2add08756
ISSN: 1252208
Appears in Collections:Scopus 1983-2021

Files in This Item:
There are no files associated with this item.


Items in SWU repository are protected by copyright, with all rights reserved, unless otherwise indicated.