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Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/15038
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dc.contributor.authorSuksamrarn S.
dc.contributor.authorKomutiban O.
dc.contributor.authorRatananukul P.
dc.contributor.authorChimnoi N.
dc.contributor.authorLartpornmatulee N.
dc.contributor.authorSuksamrarn A.
dc.date.accessioned2021-04-05T04:32:23Z-
dc.date.available2021-04-05T04:32:23Z-
dc.date.issued2006
dc.identifier.issn92363
dc.identifier.other2-s2.0-33645225308
dc.identifier.urihttps://ir.swu.ac.th/jspui/handle/123456789/15038-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-33645225308&doi=10.1248%2fcpb.54.301&partnerID=40&md5=1b715d7fd1657772b8ec277a8814a08d
dc.description.abstractThree new prenylated xanthones, mangostenones C (1), D (2), and E (3), together with 16 known xanthones 4-19, were isolated from the young fruit (7-week maturity stage) of Garcinia mangostana. The structural elucidation of the new compounds was mainly established on the basis of 1D and 2D NMR and HR-MS spectroscopic analysis. Compound 1 showed cytotoxic properties against three human cancer cell lines, epidermoid carcinoma of the mouth (KB), breast cancer (BC-1), and small cell lung cancer (NCI-H187), with IC50 values of 2.8, 3.53, and 3.72 μg/ml, respectively. Among the isolates, α-mangostin (12), the major metabolite, exhibited the most potent effects against the BC-1 cells with an IC50 value of 0.92 μg/ml, an activity greater than that of the standard drug ellipticine (IC 50=1.46 mg/ml). Compound 12 also showed the highest activity against KB cells, while gartanin (10) displayed the strongest activity against the NCI-H187 cells at the respective IC50 values of 2.08 μg/ml and 1.08 μg/ml. © 2006 Pharmaceutical Society of Japan.
dc.subject11 hydroxy 1 isomangostin
dc.subject8 desoxygartanin
dc.subjectalpha mangostin
dc.subjectantineoplastic agent
dc.subjectdemethylcalabaxanthone
dc.subjectgamma mangostin
dc.subjectgarcinone b
dc.subjectgarcinone c
dc.subjectgarcinone d
dc.subjectgarcinone e
dc.subjectgartanin
dc.subjectmangostanin
dc.subjectmangostanol
dc.subjectmangostenones c
dc.subjectmangostenones d
dc.subjectmangostenones e
dc.subjectmangostin
dc.subjectmangostinone
dc.subjectthwaitesixanthone
dc.subjectunclassified drug
dc.subjectxanthone derivative
dc.subjectarticle
dc.subjectbreast cancer
dc.subjectcancer cell culture
dc.subjectcontrolled study
dc.subjectcytotoxicity
dc.subjectdrug effect
dc.subjectdrug isolation
dc.subjectdrug structure
dc.subjectfruit
dc.subjectGarcinia mangostana
dc.subjecthuman
dc.subjecthuman cell
dc.subjectIC 50
dc.subjectlung small cell cancer
dc.subjectmass spectrometry
dc.subjectnonhuman
dc.subjectnuclear magnetic resonance
dc.subjectsquamous cell carcinoma
dc.subjectAntineoplastic Agents, Phytogenic
dc.subjectCarbohydrate Conformation
dc.subjectCell Line, Tumor
dc.subjectDrug Screening Assays, Antitumor
dc.subjectFruit
dc.subjectGarcinia
dc.subjectHumans
dc.subjectMagnetic Resonance Spectroscopy
dc.subjectSpectrometry, Mass, Fast Atom Bombardment
dc.subjectSpectrophotometry, Infrared
dc.subjectSpectrophotometry, Ultraviolet
dc.subjectXanthines
dc.titleCytotoxic prenylated xanthones from the young fruit of Garcinia mangostana
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationChemical and Pharmaceutical Bulletin. Vol 54, No.3 (2006), p.301-305
dc.identifier.doi10.1248/cpb.54.301
Appears in Collections:Scopus 1983-2021

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