Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14996
ชื่อเรื่อง: Bioactive constituents of the root bark of Artocarpus rigidus subsp. rigidus
ผู้แต่ง: Namdaung U.
Aroonrerk N.
Suksamrarn S.
Danwisetkanjana K.
Saenboonrueng J.
Arjchomphu W.
Suksamrarn A.
Keywords: 7 demethylartonol e
Artocarpus rigidus extract
artoindonesianin c
artonin F
artonol B
chromone artorigidusin
cycloartobiloxanthone
flavanoid
phenol derivative
plant extract
unclassified drug
xanthone derivative
antimicrobial activity
article
bark
breadfruit
carbon nuclear magnetic resonance
concentration response
controlled study
cytotoxicity
drug structure
human
human cell
IC 50
minimum inhibitory concentration
Mycobacterium tuberculosis
nonhuman
plant root
Plasmodium falciparum
proton nuclear magnetic resonance
structure activity relation
Animals
Artocarpus
Cell Line, Tumor
Cell Proliferation
Chromones
Drug Screening Assays, Antitumor
Flavonoids
Humans
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Molecular Structure
Mycobacterium tuberculosis
Phenols
Plant Bark
Plant Roots
Plasmodium falciparum
Reference Standards
Sensitivity and Specificity
Stereoisomerism
Structure-Activity Relationship
Xanthones
วันที่เผยแพร่: 2006
บทคัดย่อ: Investigation of the chemical constituents of the root bark of Artocarpus rigidus BLUME subsp. rigidus has led to the isolation of six, structurally diverse phenolic compounds. These included two new compounds with modified skeletons, the flavonoid 7-demethylartonol E (1) and the chromone artorigidusin (2), together with four known phenolic compounds, the xanthone artonol B (3), the flavonoid artonin F (4), the flavonoid cycloartobiloxanthone (5), and the xanthone artoindonesianin C (6). Compounds 1, 4, and 5 exhibited antiplasmodial activity against Plasmodium falciparum. All compounds showed antimycobacterial activity against Mycobacterium tuberculosis, with 4 being the most active compound (MIC 6.25 μg/ml). Compounds 5 and 6 were active against KB cells, whereas 2, 5, and 6 showed varying toxicity to BC cells. Compounds 1-3, 5, and 6 were active in the NCIH187 cytotoxicity assay, with 3 being the most active compound (IC50 1.26 μg/ml). © 2006 Pharmaceutical Society of Japan.
URI: https://ir.swu.ac.th/jspui/handle/123456789/14996
https://www.scopus.com/inward/record.uri?eid=2-s2.0-33749414443&doi=10.1248%2fcpb.54.1433&partnerID=40&md5=1a38fadda1c1d8a2295eb34703c70a27
ISSN: 92363
Appears in Collections:Scopus 1983-2021

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