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https://ir.swu.ac.th/jspui/handle/123456789/14991| Title: | Solid-phase synthesis and antibacterial activity of hydroxycinnamic acid amides and analogues against methicillin-resistant Staphylococcus aureus and vancomycin-resistant S. aureus |
| Authors: | Yingyongnarongkul B.-e. Apiratikul N. Aroonrerk N. Suksamrarn A. |
| Keywords: | hydrocinnamic acid derivative meticillin oxacillin vancomycin antibacterial activity antibiotic resistance article bacterial strain controlled study drug potency drug screening drug synthesis methicillin resistant Staphylococcus aureus minimum inhibitory concentration nonhuman solid phase synthesis Staphylococcus aureus Amides Anti-Bacterial Agents Caffeine Combinatorial Chemistry Techniques Coumaric Acids Drug Combinations Ethanol Methicillin Resistance Oxacillin Staphylococcus aureus Vancomycin Resistance methicillin resistant Staphylococcus aureus Staphylococcus aureus |
| Issue Date: | 2006 |
| Abstract: | A library of hydroxycinnamic acid amides (HCAAs) and analogues were synthesized using solid-phase synthesis technique. These compounds were screened for antibacterial against methicillin-resistant Staphylococcus aureus (MRSA) (11 strains) and vancomycin-resistant S. aureus (VRSA) (4 strains). Dihydrocaffeoyl analogues showed activity against VRSA which were better than the reference drugs, vancomycin and oxacillin. These compounds also exhibited antibacterial activity against MRSA, which were more potent than oxacillin. © 2006 Elsevier Ltd. All rights reserved. |
| URI: | https://ir.swu.ac.th/jspui/handle/123456789/14991 https://www.scopus.com/inward/record.uri?eid=2-s2.0-33749434812&doi=10.1016%2fj.bmcl.2006.08.062&partnerID=40&md5=39c9287b3f1fcba02da89c016669696b |
| ISSN: | 0960894X |
| Appears in Collections: | Scopus 1983-2021 |
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