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https://ir.swu.ac.th/jspui/handle/123456789/14950| Title: | Kaempferia parviflora ethanolic extract promoted nitric oxide production in human umbilical vein endothelial cells |
| Authors: | Wattanapitayakul S.K. Suwatronnakorn M. Chularojmontri L. Herunsalee A. Niumsakul S. Charuchongkolwongse S. Chansuvanich N. |
| Keywords: | alcohol endothelial nitric oxide synthase Kaempferia parviflora extract messenger RNA nitric oxide nitrite plant extract unclassified drug article concentration response controlled study endothelium cell gastrointestinal disease gene expression gene induction health promotion human human cell Kaempferia parviflora medicinal plant nonhuman nucleotide sequence protein expression rhizome stomach ulcer traditional medicine vascular endothelium Zingiberaceae Dose-Response Relationship, Drug Endothelial Cells Gene Expression Regulation Humans Medicine, Oriental Traditional Nitric Oxide Nitric Oxide Synthase Type II Nitric Oxide Synthase Type III Nitrites Phytotherapy Plant Extracts Plants, Medicinal Rhizome RNA, Messenger Thailand Umbilical Veins Zingiberaceae Kaempferia parviflora Zingiberaceae |
| Issue Date: | 2007 |
| Abstract: | The rhizomes of Kaempferia parviflora (KP) (Zingiberaceae) have been used in Thai traditional medicine for health promotion and for the treatment of digestive disorders and gastric ulcer. This study investigated effect of KP on endothelial function. Studies in human umbilical vein endothelial cells (HUVEC) showed that KP dose-dependently increased nitrite concentrations in culture media after 48 h incubation. eNOS mRNA and protein expression were also enhanced. The induction of eNOS mRNA was detected at 4 h and plateau at 48 h while iNOS expression was not observed. These data demonstrate that KP has a great potential for a supplemental use in vascular endothelial health promotion. © 2006 Elsevier Ireland Ltd. All rights reserved. |
| URI: | https://ir.swu.ac.th/jspui/handle/123456789/14950 https://www.scopus.com/inward/record.uri?eid=2-s2.0-33947122236&doi=10.1016%2fj.jep.2006.09.037&partnerID=40&md5=4b8589f68d1c72d28db3f942fc5e21a8 |
| ISSN: | 3788741 |
| Appears in Collections: | Scopus 1983-2021 |
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