Synthesis of bis, tris and tetra(dihydrocaffeoyl)polyamine conjugates as antibacterial agents against VRSA

Yingyongnarongkul B.-E.; Apiratikul N.; Aroonrerk N.; Suksamrarn A.

Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14853

Title:	Synthesis of bis, tris and tetra(dihydrocaffeoyl)polyamine conjugates as antibacterial agents against VRSA
Authors:	Yingyongnarongkul B.-E. Apiratikul N. Aroonrerk N. Suksamrarn A.
Keywords:	3,4-dihydroxyphenylpropionic acid antiinfective agent caffeic acid derivative dihydrocaffeic acid drug derivative spermidine animal antibiotic resistance article cell survival Cercopithecus chemical structure dose response drug effect growth, development and aging IC 50 microbiological examination penicillin resistance Staphylococcus aureus synthesis Vero cell Animals Anti-Bacterial Agents Caffeic Acids Cell Survival Cercopithecus aethiops Dose-Response Relationship, Drug Inhibitory Concentration 50 Methicillin Resistance Microbial Sensitivity Tests Molecular Structure Spermidine Staphylococcus aureus Vancomycin Resistance Vero Cells
Issue Date:	2008
Abstract:	Bis, tris and tetra(dihydrocaffeoyl)polyamine conjugates were synthesized using solid phase synthesis technique. These compounds were screened for antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) (11 strains) and vancomycin-resistant S. aureus (VRSA) (4 strains). Bis, tris and tetra(dihydrocaffeoyl)polyamine analogues showed antibacterial activity against VRSA which were better than the reference drugs, vancomycin. Tetra(dihydrocaffeoyl) polyamine conjugate exhibited the highest activity. These compounds showed no cytotoxicity against vero cells. © 2008 The Pharmaceutical Society of Korea.
URI:	https://ir.swu.ac.th/jspui/handle/123456789/14853 https://www.scopus.com/inward/record.uri?eid=2-s2.0-45749097459&doi=10.1007%2fs12272-001-1215-4&partnerID=40&md5=9d9df22ae5f6bc2755552008dc25c54d
ISSN:	2536269
Appears in Collections:	Scopus 1983-2021

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