Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14851
ชื่อเรื่อง: Lower urinary tract symptoms and its potential relation with late-onset hypogonadism
ผู้แต่ง: Pradidarcheep W.
Keywords: androgen receptor
angiotensin II
endothelin
estrogen receptor
nitric oxide
Rho kinase
testosterone
aging
castration
disease course
enzyme activation
enzyme activity
human
hypogonadism
lower urinary tract symptom
nonhuman
note
priority journal
prostate hypertrophy
Age of Onset
Aging
Animals
Humans
Hypogonadism
Intra-Abdominal Fat
Male
Metabolic Syndrome X
Nitric Oxide
Rabbits
Rats
Receptors, Androgen
Testosterone
Urinary Tract
Urination Disorders
วันที่เผยแพร่: 2008
บทคัดย่อ: The study of the health status of the aging male takes presently a more integrative approach and it appears that ailments typical of male aging, such as lower urinary tract symptoms (LUTS), (visceral) obesity, metabolic syndrome and erectile failure are significantly interrelated. A common denominator of the above ailments is lower-than-normal testosterone levels occurring in a significant proportion of elderly men. This review addresses the potential connections between LUTS and late-onset hypogonadism. In animal studies there appear to be androgen and estrogen receptors in the urothelium and smooth muscle cells of the urethra and bladder of the rat and rabbit, as well as in the neurons in the autonomic ganglia of the prostatic plexus of the male rat. Upon castration electrically evoked relaxations of the smooth muscle of the prostatic urethra were decreased. There is a Rho-kinase activation/endothelin pathway; possibly involved in the increased smooth muscle activity found in both LUTS/benign prostate hyperplasia. Nitric oxide (NO) appears to have a smooth muscle relaxing effect in the urogenital organs. Studies in humans have convincingly shown that phosphodiestererase inhibitors have a beneficial effect on LUTS. More intervention studies should be undertaken to test the clinical validity of the theoretically plausible interrelationship between LUTS and late-onset hypogonadism. © 2008 Informa UK Ltd.
URI: https://ir.swu.ac.th/jspui/handle/123456789/14851
https://www.scopus.com/inward/record.uri?eid=2-s2.0-45849140201&doi=10.1080%2f13685530801954026&partnerID=40&md5=38fd859477a0e456809c781593e8588b
ISSN: 13685538
Appears in Collections:Scopus 1983-2021

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