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Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14843
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dc.contributor.authorPrachayasittikul S.
dc.contributor.authorManam P.
dc.contributor.authorChinworrungsee M.
dc.contributor.authorIsarankura-Na-ayudhya C.
dc.contributor.authorRuchirawat S.
dc.contributor.authorPrachayasittikul V.
dc.date.accessioned2021-04-05T04:31:58Z-
dc.date.available2021-04-05T04:31:58Z-
dc.date.issued2009
dc.identifier.issn14203049
dc.identifier.other2-s2.0-73349142009
dc.identifier.urihttps://ir.swu.ac.th/jspui/handle/123456789/14843-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-73349142009&doi=10.3390%2fmolecules14114414&partnerID=40&md5=0dafd56146fb6c95cc791de3be2ea54c
dc.description.abstractThis study investigated bioactive extracts of Polyalthia debilis (Annonaceae) with antimicrobial, antimalarial and cytotoxic activities. Extensive chromatographic isolations provided azafluorenone alkaloids; onychine (1) and 7-methoxyonychine (2) together with a mixture of β-sitosterol and stigmasterol. The two alkaloids were isolated from the P. debilis for the first time. Isolated fractions containing a mixture of triterpenoids (C7, C8 and C9) exhibited the most potent antimicrobial activity against many bacterial strains with minimum inhibitory concentration of 64 μg/mL. Fractions with antimalarial and cytotoxic activities were also observed. The findings suggest the potential use of P. debilis in medicinal applications.
dc.subjectalkaloid
dc.subjectantiinfective agent
dc.subjectantimalarial agent
dc.subjectflavanone derivative
dc.subjectonychine
dc.subjectplant extract
dc.subjectpyridone derivative
dc.subjectsitosterol
dc.subjectsitosterol derivative
dc.subjectstigmasterol
dc.subjecttriterpene
dc.subjectarticle
dc.subjectcell line
dc.subjectcell survival
dc.subjectchemical structure
dc.subjectchemistry
dc.subjectdrug effect
dc.subjecthuman
dc.subjectmicrobiological examination
dc.subjectPlasmodium falciparum
dc.subjectPolyalthia
dc.subjecttumor cell line
dc.subjectAlkaloids
dc.subjectAnti-Infective Agents
dc.subjectAntimalarials
dc.subjectCell Line
dc.subjectCell Line, Tumor
dc.subjectCell Survival
dc.subjectFlavanones
dc.subjectHumans
dc.subjectMicrobial Sensitivity Tests
dc.subjectMolecular Structure
dc.subjectPlant Extracts
dc.subjectPlasmodium falciparum
dc.subjectPolyalthia
dc.subjectPyridones
dc.subjectSitosterols
dc.subjectStigmasterol
dc.subjectTriterpenes
dc.titleBioactive azafluorenone alkaloids from Polyalthia debilis (pierre) finet & Gagnep.
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationMolecules. Vol 14, No.11 (2009), p.4414-4424
dc.identifier.doi10.3390/molecules14114414
Appears in Collections:Scopus 1983-2021

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