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Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14762
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dc.contributor.authorWeecharangsan W.
dc.contributor.authorYu B.
dc.contributor.authorLiu S.
dc.contributor.authorPang J.X.
dc.contributor.authorLee L.J.
dc.contributor.authorMarcucci G.
dc.contributor.authorLee R.J.
dc.date.accessioned2021-04-05T03:37:05Z-
dc.date.available2021-04-05T03:37:05Z-
dc.date.issued2010
dc.identifier.issn2507005
dc.identifier.other2-s2.0-77649246832
dc.identifier.urihttps://ir.swu.ac.th/jspui/handle/123456789/14762-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-77649246832&partnerID=40&md5=58a80b4e5e45b2b1ee0f7b97fed14f3f
dc.description.abstractBackground: Disulfide-linked oligodeoxyribonucleotide (ODN) liposomes were formulated and evaluated for the delivery of antisense ODN G3139 in KB human oral carcinoma cells. Materials and Methods: Liposomes composed of 1,2-di-(9Z-octadecenoyl)-3-trimethylammo-nium-propane(DOTAP)/egg phosphatidylcholine/α-tocopheryl polyethylene glycol 1000 succinate were incorporated with hydrophobized disulfide-linked ODN. Disulfide-linked ODN liposomes were characterized for their size, ODN intracellular delivery, Bcl-2 mRNA and protein expression, growth inhibition, and chemosensitization. Results: Intracellular delivery of ODN with disulfide-linked ODN liposomes was more efficient than that with non-liposomal hydrophobized disulfide-linked ODN. Treatment of the cells with disulfide-linked ODN liposomes resulted in efficient Bcl-2 down-regulation greater than that with hydrophobized disulfide-linked ODN and consistent with that of cellular growth inhibition and the sensitization to daunorubicin in KB cells. Disulfide-linked ODN liposomes exhibited superior colloidal stability during 5-week storage. Conclusion: Disulfide-linked liposomes are effective delivery vehicles for antisense ODN.
dc.subject1,2 dioleoyl 3 trimethylammoniopropane
dc.subjectdaunorubicin
dc.subjectdisulfide linked liposome
dc.subjectliposome
dc.subjectmacrogol derivative
dc.subjectmessenger RNA
dc.subjectoblimersen
dc.subjectphosphatidylcholine
dc.subjectpolyethylene glycol 1000 succinate
dc.subjectprotein bcl 2
dc.subjectunclassified drug
dc.subjectarticle
dc.subjectcell growth
dc.subjectcell strain KB
dc.subjectchemosensitization
dc.subjectcontrolled study
dc.subjectdown regulation
dc.subjectgrowth inhibition
dc.subjecthuman
dc.subjecthuman cell
dc.subjectintracellular transport
dc.subjectmouth carcinoma
dc.subjectnonviral gene delivery system
dc.subjectpriority journal
dc.subjectprotein expression
dc.subjectAntibiotics, Antineoplastic
dc.subjectCell Growth Processes
dc.subjectColloids
dc.subjectDaunorubicin
dc.subjectDisulfides
dc.subjectDown-Regulation
dc.subjectDrug Stability
dc.subjectGenes, bcl-2
dc.subjectHumans
dc.subjectKB Cells
dc.subjectLiposomes
dc.subjectOligodeoxyribonucleotides, Antisense
dc.subjectTransfection
dc.titleDisulfide-linked liposomes: Effective delivery vehicle for Bcl-2 antisense oligodeoxyribonucleotide G3139
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationAnticancer Research. Vol 30, No.1 (2010), p.31-38
Appears in Collections:Scopus 1983-2021

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