Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14709
ชื่อเรื่อง: Estrogen reduces BDNF level, but maintains dopaminergic cell density in the striatum of MPTP mouse model
ผู้แต่ง: Tripanichkul W.
Gerdprasert O.
Jaroensuppaperch E.-O.
Keywords: 1,2,3,6 tetrahydro 1 methyl 4 phenylpyridine
brain derived neurotrophic factor
estradiol
tyrosine 3 monooxygenase
animal experiment
animal model
article
C57BL 6 mouse
cell density
controlled study
corpus striatum
dopaminergic nerve cell
drug effect
female
immunohistochemistry
immunoreactivity
innervation
male
mouse
nerve fiber
nonhuman
optical density
preservation
protein expression
upregulation
Animals
Axons
Brain-Derived Neurotrophic Factor
Corpus Striatum
Disease Models, Animal
Disease Progression
Dopamine
Down-Regulation
Estrogens
Male
Mice
Mice, Inbred C57BL
Neuroprotective Agents
Parkinsonian Disorders
Substantia Nigra
Wallerian Degeneration
วันที่เผยแพร่: 2010
บทคัดย่อ: Degeneration of dopaminergic (DA) axons in the striatum triggers upregulation of striatal trophic activity and striatal DA neuronal number in animal models of Parkinson's disease (PD). The present study investigated the effects of 17β-estradiol (E2) on brain-derived neurotrophic factor (BDNF) expression and the density of DA neurons in the striatum of 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP) mouse model in correlation with nigrostriatal DA innervation. Adult male C57Bl/6 mice were treated with E2 or vehicle for 11 days. Following 5 days of E2 or vehicle pretreatment, animals were injected with MPTP on day 6. On day 11, all mice were sacrificed, and the striatum were collected and processed for tyrosine hydroxylase (TH) and BDNF immunohistochemistry. Striatal TH-immunoreactive (IR) neurons were counted. Extent of DA innervation and BDNF expression in the striatum were assessed by measuring optical density of TH and BDNF immunoreactivity, respectively. Pretreatment with E2 partially prevented DA denervation and decreased striatal BDNF upregulation triggered by MPTP, but maintained the density of striatal TH-IR neurons to that observed in MPTP group. These findings suggest that estrogen protection of nigrostriatal DA axons against MPTP as well as preservation of the striatal TH-IR cell density in MPTP/E2 mice may be not mediated by BDNF. Copyright © 2010 Informa Healthcare USA, Inc.
URI: https://ir.swu.ac.th/jspui/handle/123456789/14709
https://www.scopus.com/inward/record.uri?eid=2-s2.0-77954206062&doi=10.3109%2f00207451003721892&partnerID=40&md5=c7f3a86210fa88b0b5347b42f85418ee
ISSN: 207454
Appears in Collections:Scopus 1983-2021

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