Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14670
ชื่อเรื่อง: Potential of xanthones from tropical fruit mangosteen as anti-cancer agents: Caspase-dependent apoptosis induction in vitro and in mice
ผู้แต่ง: Watanapokasin R.
Jarinthanan F.
Jerusalmi A.
Suksamrarn S.
Nakamura Y.
Sukseree S.
Uthaisang-Tanethpongtamb W.
Ratananukul P.
Sano T.
Keywords: Apoptosis
Cancer Chemotherapy
Caspases
Garcinia mangostana L (mangosteen)
Mangostin
Activation analysis
Cell culture
Cell death
Chemotherapy
Tumors
antineoplastic agent
caspase
caspase 3
caspase 8
cytochrome c
mangosteen xanthone
unclassified drug
xanthone derivative
adenocarcinoma
animal experiment
animal model
animal tissue
antineoplastic activity
apoptosis
article
cell proliferation
cell structure
cell viability
colon adenocarcinoma
colorectal cancer
controlled study
DNA fragmentation
drug cytotoxicity
enzyme activation
enzyme activity
enzyme release
fruit
growth inhibition
high performance liquid chromatography
histopathology
human
human cell
in vitro study
in vivo study
male
mangosteen
mouse
nonhuman
signal transduction
tumor cell
tumor growth
tumor volume
Animals
Antineoplastic Agents, Phytogenic
Apoptosis
Caspases
Cell Line, Tumor
Cell Proliferation
Colorectal Neoplasms
Enzyme Activation
Female
Fruit
Garcinia mangostana
Humans
Mice
Mice, Nude
Neoplasms
Plant Extracts
Xanthones
Garcinia mangostana
Mus
วันที่เผยแพร่: 2010
บทคัดย่อ: The pericarp of mangosteen (Garcinia mangostana L.) is rich in various xanthones that are known to possess unique biological activities. In this work, we characterized the anti-proliferative and cytotoxic activities of mangosteen xanthones both in vitro and in mice. In vitro analysis with a human colorectal adenocarcinoma cell line, COLO 205, showed that mangosteen xanthones not only inhibit the proliferation of target cells but also induce their death by apoptosis that involves the activation of the caspase cascade. In vivo analysis using a mouse subcutaneous tumor model with COLO 205 cells showed that, at relatively low doses, the growth of tumors was repressed upon intratumoral administration of mangosteen xanthones. When a higher dose of mangosteen xanthones was administered, the size of tumors was reduced gradually, and, in some mice, the disappearance of tumors was seen. Histopathological evaluation and biochemical analysis of tumors that received mangosteen xanthones indicate the induction of apoptosis in tumors, which resulted in the repression of their growth and the reduction of their sizes. These results demonstrate the potential of mangosteen xanthones to serve as anti-cancer agents for the chemotherapy of cancer. © 2010 Springer Science+Business Media, LLC.
URI: https://ir.swu.ac.th/jspui/handle/123456789/14670
https://www.scopus.com/inward/record.uri?eid=2-s2.0-77955920713&doi=10.1007%2fs12010-009-8903-6&partnerID=40&md5=0910ecf01c2abf5a04a3f50a0532414a
ISSN: 2732289
Appears in Collections:Scopus 1983-2021

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