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ชื่อเรื่อง: Correlation of low levels of serum carotenoids with increased risk of cardiovascular diseases
ผู้แต่ง: Rerksuppaphol S.
Chansiri K.
Rerksuppaphol L.
Loetthiraphan S.
Chansiri G.
Keywords: alpha carotene
alpha tocopherol
beta carotene
beta cryptoxanthin
delta tocopherol
superoxide dismutase
alpha carotene blood level
alpha tocopherol blood level
beta carotene blood level
beta cryptoxanthin blood level
cardiovascular disease
cardiovascular risk
carotenoid blood level
controlled study
delta tocopherol blood level
enzyme activity
high performance liquid chromatography
lycopene blood level
major clinical study
retinol blood level
self report
vitamin blood level
xanthophyll blood level
zeaxanthin blood level
วันที่เผยแพร่: 2010
บทคัดย่อ: Background & Objective: Cardiovascular disease (CVD) is one of major cause of morbidity and mortality worldwide. Evidences from epidemiological and clinical studies suggest a possible correlation between antioxidant levels and the cardiovascular disease risk. Few data are reported concerning oriental population. Objective of this study is to investigate the serum antioxidant levels in cardiovascular disease patients in comparison to healthy controls in Thai population. Methods: Forty CVD patients and forty self-reported healthy volunteers were enrolled in the study. Serum carotenoids levels, including lutein, zeaxanthin, β-cryptoxanthin, lycopene, α and β-carotene, and retinol and tocopherols (alpha-and delta-) levels were quantified with HPLC procedure. Superoxide dismutase (SOD) and catalase activity was evaluated through an enzymatic assay. Results: Lutein, zeaxanthin, and beta-cryptoxanthin in CVD patients were significantly lower than in controls (0.84 versus 1.79 ng/ml, 3.08 versus 5.48 ng/ml, and 3.01 versus 5.20 ng/ml, respectively; p <0.05), while SOD and catalase activity was significantly higher in CVD patients than in controls (91.75 versus 63.63 ng/ml and 2.76 versus 2.09 nmol/min/ ml, respectively; p <0.05). Interpretation & Conclusion: These data reveal that CVD patients have lower levels of some non-enzymatic antioxidants but have higher enzymatic antioxidants than those in the healthy controls.
ISSN: 9702067
Appears in Collections:Scopus 1983-2021

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