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Title: Molecular targets of apigenin in colorectal cancer cells: Involvement of p21, NAG-1 and p53
Authors: Zhong Y.
Krisanapun C.
Lee S.-H.
Nualsanit T.
Sams C.
Peungvicha P.
Baek S.J.
Keywords: antineoplastic agent
ATM protein
protein kinase C gamma
protein nag 1
protein p21
protein p53
unclassified drug
animal experiment
animal model
antineoplastic activity
cancer cell
colorectal cancer
controlled study
enzyme activation
human cell
in vitro study
liquid chromatography
priority journal
protein expression
protein phosphorylation
reverse transcription polymerase chain reaction
signal transduction
transient transfection
Western blotting
Antineoplastic Agents
Cell Proliferation
Colorectal Neoplasms
Cyclin-Dependent Kinase Inhibitor p21
Enzyme Inhibitors
Growth Differentiation Factor 15
Tumor Cells, Cultured
Tumor Suppressor Protein p53
Issue Date: 2010
Abstract: Persuasive epidemiological and experimental evidence suggests that dietary flavonoids have anti-cancer activity. Since conventional therapeutic and surgical approaches have not been able to fully control the incidence and outcome of most cancer types, including colorectal neoplasia, there is an urgent need to develop alternative approaches for the management of cancer. We sought to develop the best flavonoids for the inhibition of cell growth, and apigenin (flavone) proved to be the most promising compound in colorectal cancer cell growth arrest. Subsequently, we found that pro-apoptotic proteins (NAG-1 and p53) and cell cycle inhibitor (p21) were induced in the presence of apigenin, and kinase pathways, including PKCδ and ataxia telangiectasia mutated (ATM), play an important role in activating these proteins. The data generated by in vitro experiments were confirmed in an animal study using APC MIN+ mice. Apigenin is able to reduce polyp numbers, accompanied by increasing p53 activation through phosphorylation in animal models. Our data suggest apparent beneficial effects of apigenin on colon cancer. © 2010 Elsevier Ltd. All rights reserved.
ISSN: 9598049
Appears in Collections:Scopus 1983-2021

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