Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14623
ชื่อเรื่อง: Middle cerebral artery peak systolic velocity in fetuses with homozygous alpha-thalassemia-1: Case series
ผู้แต่ง: Raungrongmorakot K.
Chaemsaithong P.
Keywords: alpha thalassemia
article
blood flow velocity
brain circulation
case report
cordocentesis
echography
female
fetus
fetus echography
genetics
gestational age
homozygote
human
methodology
middle cerebral artery
pathophysiology
physiology
placenta
predictive value
pregnancy
systole
alpha-Thalassemia
Blood Flow Velocity
Cerebrovascular Circulation
Cordocentesis
Female
Fetus
Gestational Age
Homozygote
Humans
Middle Cerebral Artery
Placenta
Predictive Value of Tests
Pregnancy
Systole
Ultrasonography, Prenatal
วันที่เผยแพร่: 2010
บทคัดย่อ: Objectives: The objective of this study is to evaluate the potential usefulness of middle cerebral artery peak systolic velocity (MCA-PSV) as a non-invasive means of detecting an anemic fetus from homozygous alphathalassemia- 1 Material and Method: We observed four cases of referrals with complicated pregnancies in which the fetuses were suspected with homozygous alpha-thalassemia-1. Three out of four cases involved hydrop fetalis, detected through previous ultrasounds, while the remaining case was referred for prenatal diagnosis. Subsequently, we performed a detailed ultrasound and fetal MCA-PSV in all cases, and to confirm the diagnosis, we also performed cordocentesis. Results: With all the four cases having the gestational age range from 18 to 27 weeks, three showed hydrop fetalis. The remaining case, the 18-week gestational age fetus referred for prenatal diagnosis, showed an increase in the cardiothoracic ratio without other signs of hydrop fetalis. MCA-PSV suggested the presence of fetal anemia in all cases (with the velocity ranging from 37.3 to 62.2 cm/sec). The results obtained from cordocentesis confirmed fetal anemia and homozygous alpha-thalassemia-1 in all cases. Conclusion: Peak systolic velocity of fetal middle cerebral artery can predict anemia in fetus affected with homozygous alpha-thalassemia-1 disease.
URI: https://ir.swu.ac.th/jspui/handle/123456789/14623
https://www.scopus.com/inward/record.uri?eid=2-s2.0-79952269419&partnerID=40&md5=075a56215a11d9280a41ea859607062c
ISSN: 1252208
Appears in Collections:Scopus 1983-2021

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