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https://ir.swu.ac.th/jspui/handle/123456789/14617| ชื่อเรื่อง: | A new sulfoxide analog of 1,2,3,6-tetrahydrophenylpyridine and antimicrobial activity |
| ผู้แต่ง: | Prachayasittikul S. Pingaew R. Worachartcheewan A. Ruchirawat S. Prachayasittikul V. |
| Keywords: | 1,2,3,6 tetrahydro 4 phenylpyridine n acetyl 2(1 adamantylsulfoxo) 3 acetoxy 4 phenyl 6 hydroxy 1,2,3,6 tetrahydropyridine sulfoxide unclassified drug antimicrobial activity article controlled study drug structure drug synthesis human infrared radiation mass spectrometry minimum inhibitory concentration Moraxella catarrhalis nonhuman nuclear magnetic resonance Streptococcus pyogenes thin layer chromatography ultraviolet radiation Moraxella catarrhalis Streptococcus pyogenes |
| วันที่เผยแพร่: | 2010 |
| บทคัดย่อ: | Bioactivities of thiotetrahydropyridines were previously described. Herein, a novel bioactive sulfoxide analog; N-acetyl-2-(1-adamantylsulfoxo)-3-acetoxy-4-phenyl-6-hydroxy-1,2,3,6-tet rahydropyridine (3) from the deoxydative substitution of 4-phenylpyridine 1-oxide is reported. Its structure was elucidated using spectral data including 2D-NMR, MS, IR and UV. The sulfoxide 3 exhibited antibacterial activity against Moraxella catarrhalis and Streptococcus pyogenes with minimum inhibitory concentration of 128 and 256 μg/mL, respectively. |
| URI: | https://ir.swu.ac.th/jspui/handle/123456789/14617 https://www.scopus.com/inward/record.uri?eid=2-s2.0-79151486711&partnerID=40&md5=fd263d24f05e311169737354b58b6085 |
| ISSN: | 16112156 |
| Appears in Collections: | Scopus 1983-2021 |
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