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Title: A new sulfoxide analog of 1,2,3,6-tetrahydrophenylpyridine and antimicrobial activity
Authors: Prachayasittikul S.
Pingaew R.
Worachartcheewan A.
Ruchirawat S.
Prachayasittikul V.
Keywords: 1,2,3,6 tetrahydro 4 phenylpyridine
n acetyl 2(1 adamantylsulfoxo) 3 acetoxy 4 phenyl 6 hydroxy 1,2,3,6 tetrahydropyridine
unclassified drug
antimicrobial activity
controlled study
drug structure
drug synthesis
infrared radiation
mass spectrometry
minimum inhibitory concentration
Moraxella catarrhalis
nuclear magnetic resonance
Streptococcus pyogenes
thin layer chromatography
ultraviolet radiation
Moraxella catarrhalis
Streptococcus pyogenes
Issue Date: 2010
Abstract: Bioactivities of thiotetrahydropyridines were previously described. Herein, a novel bioactive sulfoxide analog; N-acetyl-2-(1-adamantylsulfoxo)-3-acetoxy-4-phenyl-6-hydroxy-1,2,3,6-tet rahydropyridine (3) from the deoxydative substitution of 4-phenylpyridine 1-oxide is reported. Its structure was elucidated using spectral data including 2D-NMR, MS, IR and UV. The sulfoxide 3 exhibited antibacterial activity against Moraxella catarrhalis and Streptococcus pyogenes with minimum inhibitory concentration of 128 and 256 μg/mL, respectively.
ISSN: 16112156
Appears in Collections:Scopus 1983-2021

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