Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14541
ชื่อเรื่อง: Effects of Curcuma comosa on the expression of atherosclerosis-related cytokine genes in rabbits fed a high-cholesterol diet
ผู้แต่ง: Charoenwanthanang P.
Lawanprasert S.
Phivthong-Ngam L.
Piyachaturawat P.
Sanvarinda Y.
Porntadavity S.
Keywords: cholesterol
Curcuma comosa extract
cytokine
interleukin 1
interleukin 10
monocyte chemotactic protein 1
plant extract
simvastatin
transforming growth factor beta
tumor necrosis factor alpha
unclassified drug
abdominal aorta
animal experiment
animal model
antiinflammatory activity
article
atherosclerosis
cholesterol diet
controlled study
Curcuma comosa
drug effect
drug safety
gene expression regulation
hypercholesterolemia
liver toxicity
male
medicinal plant
nonhuman
nucleotide sequence
protein expression
rabbit
Animals
Aorta, Abdominal
Atherosclerosis
Base Sequence
Cholesterol, Dietary
Curcuma
Cytokines
DNA Primers
Hypercholesterolemia
Liver
Liver Function Tests
Male
Plants, Medicinal
Rabbits
Reverse Transcriptase Polymerase Chain Reaction
Curcuma comosa
Oryctolagus cuniculus
วันที่เผยแพร่: 2011
บทคัดย่อ: Aim of the study: Curcuma comosa has been known to have potential use in cardiovascular diseases, but its immunoregulatory role in atherosclerosis development and liver toxicity has not been well studied. We therefore investigated the effects of Curcuma comosa on the expression of atherosclerosis-related cytokine genes in rabbits fed a high-cholesterol diet. Materials and methods: Twelve male New Zealand White rabbits were treated with 1.0% cholesterol for one month and were subsequently treated with 0.5% cholesterol either alone, or in combination with 5 mg/kg/day of simvastatin or with 400 mg/kg/day of Curcuma comosa powder for three months. The expression of IL-1, MCP-1, TNF-α, IL-10, and TGF-β in the isolated abdominal aorta and liver were determined by real-time RT-PCR. Liver toxicity was determined by hepatic enzyme activity. Results: Curcuma comosa significantly decreased the expression of pro-inflammatory cytokines, leading to a stronger reduction in IL-1, MCP-1, and TNF-α expression compared to that was suppressed by simvastatin treatment. However, neither Curcuma comosa nor simvastatin affected the expression of anti-inflammation cytokines. In the liver, Curcuma comosa insignificantly decreased the expression of pro-inflammatory cytokines and significantly increased the expression of the anti-inflammatory cytokine IL-10 without altering the activity of hepatic enzymes. In contrast, simvastatin significantly increased the MCP-1 and TNF-α expressions and serum ALT level, without affecting the expression of anti-inflammatory cytokines. Conclusions: In this study, we demonstrated that Curcuma comosa exerts anti-inflammatory activity in the aorta and liver without causing liver toxicity, indicating that Curcuma comosa is a potential candidate as an alternative agent in cardiovascular disease therapy. © 2011 Elsevier Ireland Ltd.
URI: https://ir.swu.ac.th/jspui/handle/123456789/14541
https://www.scopus.com/inward/record.uri?eid=2-s2.0-79954425672&doi=10.1016%2fj.jep.2011.01.006&partnerID=40&md5=c8d615d4ebfb981f86602c54b6c240f0
ISSN: 3788741
Appears in Collections:Scopus 1983-2021

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