Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14526
ชื่อเรื่อง: Role of angiotensin II on protein expression of renal nitric oxide synthase in unilateral ureteral obstructive rat
ผู้แต่ง: Tanyong J.
Eiam-Ong S.
Phansuwan P.
Eiam-Ong S.
Keywords: angiotensin 1 receptor antagonist
angiotensin II
dipeptidyl carboxypeptidase inhibitor
endothelial nitric oxide synthase
article
cell infiltration
glomerulus
histopathology
kidney cortex
kidney medulla
kidney tubule cell
male
nonhuman
protein expression
rat
structure analysis
unilateral ureteral obstruction
ureter obstruction
วันที่เผยแพร่: 2011
บทคัดย่อ: Background: In the kidney, angiotensin II (ANG II) and nitric oxide (NO) can stimulate each other. Unilateral ureteral obstruction (UUO) activates both substances, where ANG II is stimulated first and NO is augmented later. Objective: Investigate the role of ANG II on renal nitric oxide synthase (NOS) protein expression in UUO. Methods: Male Wistar rats were divided into sham and UUO. The UUO rats were treated separately with water, angiotensin converting enzyme inhibitor (ACEI), or angiotensin receptor type 1 blocker (ARB) for one day before UUO and continuously for one or seven days after the operation. The endothelial NOS (eNOS) and inducible NOS (iNOS) protein expressions were examined in histology. Results: By immunohistochemistry, renal eNOS protein expression in the sham group showed staining in glomerulus and tubular epithelial cells in the cortex and medulla. UUO for one or seven days increased eNOS protein expression. ACEI or ARB reduced the heightened expression caused by UUO in 1-day group. However, in 7-day group, the elevated expression was maintained in the cortex, but was further increased in the medulla after ACEI or ARB administration. Both 1-day and 7-day UUO, with or without angiotensin blockade agents, caused no change in iNOS protein expression. One-day UUO resulted in mild tubular dilatation and cell infiltration. ACEI or ARB could attenuate structural alterations. The 7-day UUO rats demonstrated progressively morphological changes. ACEI was more effective than ARB in reducing tissue destruction. Conclusion: In UUO, angiotensin blockade could attenuate renal eNOS protein expression in 1-day UUO group but not in 7-day UUO animals. The inhibition of angiotensin system ameliorates nephropathy induced by UUO.
URI: https://ir.swu.ac.th/jspui/handle/123456789/14526
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84871658507&doi=10.5372%2f1905-7415.0503.044&partnerID=40&md5=471d3346865c7fea2a81c158a32f5005
ISSN: 19057415
Appears in Collections:Scopus 1983-2021

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