1. Srinakharinwirot University Institutional Repository
  2. Articles from Academic Databases : SCOPUS
  3. Scopus 1983-2021
Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14499
Full metadata record
DC FieldValueLanguage
dc.contributor.authorChittasupho C.
dc.contributor.authorSestak J.
dc.contributor.authorShannon L.
dc.contributor.authorSiahaan T.J.
dc.contributor.authorVines C.M.
dc.contributor.authorBerkland C.
dc.date.accessioned2021-04-05T03:35:12Z-
dc.date.available2021-04-05T03:35:12Z-
dc.date.issued2014
dc.identifier.issn15438384
dc.identifier.other2-s2.0-84891756544
dc.identifier.urihttps://ir.swu.ac.th/jspui/handle/123456789/14499-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84891756544&doi=10.1021%2fmp4003909&partnerID=40&md5=75df0a33de86306173559d9484569faf
dc.description.abstractA novel oxime grafting scheme was utilized to conjugate an ICAM-1 ligand (LABL), a cellular antigen ovalbumin (OVA), or both peptides simultaneously to hyaluronic acid (HA). Samples of HA only and the various peptide grafted HA were found to bind to dendritic cells (DCs). HA with grafted LABL and OVA showed the greatest binding to DCs. Dendritic cells treated with HA, HA with grafted LABL, or HA with grafted LABL and OVA significantly suppressed T cell and DC conjugate formation and T cell proliferation and reduced proinflammatory cytokine production compared to untreated cells. These results suggest that HA serves as an effective backbone for multivalent ligand presentation for inhibiting T cell response to antigen presentation. In addition, multivalent display of both antigen and an ICAM-1 inhibitor (LABL) may enhance binding to DCs and could potentially disrupt cellular signaling leading to autoimmunity. © 2013 American Chemical Society.
dc.subjectgamma interferon
dc.subjecthyaluronic acid
dc.subjectintercellular adhesion molecule 1
dc.subjectinterleukin 10
dc.subjectinterleukin 17
dc.subjectinterleukin 4
dc.subjectovalbumin
dc.subjectpolymer
dc.subjecttumor necrosis factor alpha
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectantigen presentation
dc.subjectarticle
dc.subjectcell adhesion
dc.subjectcell culture
dc.subjectcell surface
dc.subjectconjugation
dc.subjectcontrolled study
dc.subjectcytokine production
dc.subjectdendritic cell
dc.subjectfluorescence microscopy
dc.subjectimmune response
dc.subjectin vitro study
dc.subjectlymphocyte proliferation
dc.subjectmacrophage
dc.subjectmouse
dc.subjectneutrophil
dc.subjectnonhuman
dc.subjectpeptide synthesis
dc.subjectpriority journal
dc.subjectprotein binding
dc.subjectT lymphocyte
dc.subjectAnimals
dc.subjectAntigen-Presenting Cells
dc.subjectCD8-Positive T-Lymphocytes
dc.subjectCells, Cultured
dc.subjectCytokines
dc.subjectDendritic Cells
dc.subjectEnzyme-Linked Immunosorbent Assay
dc.subjectHyaluronic Acid
dc.subjectIntercellular Adhesion Molecule-1
dc.subjectLymphocyte Activation
dc.subjectMice
dc.subjectMice, Inbred C57BL
dc.subjectOvalbumin
dc.subjectPeptide Fragments
dc.subjectPolymers
dc.subjectT-Lymphocytes, Regulatory
dc.titleHyaluronic acid graft polymers displaying peptide antigen modulate dendritic cell response in vitro
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationMolecular Pharmaceutics. Vol 11, No.1 (2014), p.367-373
dc.identifier.doi10.1021/mp4003909
Appears in Collections:Scopus 1983-2021

Files in This Item:
There are no files associated with this item.
Show simple item record


Items in SWU repository are protected by copyright, with all rights reserved, unless otherwise indicated.