1. Srinakharinwirot University Institutional Repository
  2. Articles from Academic Databases : SCOPUS
  3. Scopus 1983-2021
Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14481
Full metadata record
DC FieldValueLanguage
dc.contributor.authorUngwitayatorn J.
dc.contributor.authorWiwat C.
dc.contributor.authorSamee W.
dc.contributor.authorNunthanavanit P.
dc.contributor.authorPhosrithong N.
dc.date.accessioned2021-04-05T03:35:07Z-
dc.date.available2021-04-05T03:35:07Z-
dc.date.issued2011
dc.identifier.issn222860
dc.identifier.other2-s2.0-79961032360
dc.identifier.urihttps://ir.swu.ac.th/jspui/handle/123456789/14481-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-79961032360&doi=10.1016%2fj.molstruc.2011.06.035&partnerID=40&md5=007ee7698fbe2e5de50c88d3b44e8787
dc.description.abstractNovel chromone derivatives with a benzopyran-4-one scaffold have been prepared by the one-pot cyclization reaction. The in vitro inhibitory activity of these new compounds towards HIV-1 protease have been evaluated using stop time HPLC method as the preliminary screening. The most potent compound, 7,8-dihydroxy-2-(3′-trifluoromethyl phenyl)-3-(3″- trifluoromethylbenzoyl)chromone (32), showed IC50 = 0.34 μM. The molecular docking study supported results from experimental activity testing and also provided structure-activity relationship of this series. © 2011 Elsevier B.V. All rights reserved.
dc.subjectChromone derivatives
dc.subjectChromones
dc.subjectCyclization reactions
dc.subjectHIV-1 protease
dc.subjectHIV-1 protease inhibitors
dc.subjectHPLC method
dc.subjectIn-vitro
dc.subjectIn-vitro evaluation
dc.subjectInhibitory activity
dc.subjectMolecular docking
dc.subjectOne pot
dc.subjectPotent compounds
dc.subjectStructure activity relationships
dc.subjectTrifluoromethyl
dc.subjectCyclization
dc.subjectMolecular modeling
dc.subjectScaffolds
dc.subjectSynthesis (chemical)
dc.subjectDocking
dc.subjectHuman immunodeficiency virus
dc.subjectHuman immunodeficiency virus 1
dc.titleSynthesis, in vitro evaluation, and docking studies of novel chromone derivatives as HIV-1 protease inhibitor
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationJournal of Molecular Structure. Vol 1001, (2011), p.152-161
dc.identifier.doi10.1016/j.molstruc.2011.06.035
Appears in Collections:Scopus 1983-2021

Files in This Item:
There are no files associated with this item.
Show simple item record


Items in SWU repository are protected by copyright, with all rights reserved, unless otherwise indicated.