Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14478
ชื่อเรื่อง: Evaluation of an ethnopharmacologically selected Bhutanese medicinal plants for their major classes of Phytochemicals and biological activities
ผู้แต่ง: Wangchuk P.
Keller P.A.
Pyne S.G.
Taweechotipatr M.
Tonsomboon A.
Rattanajak R.
Kamchonwongpaisan S.
Keywords: Aconitum laciniatum extract
Ajania nubigena extract
alkaloid
Androsace strigillosa extract
antitrypanosomal agent
Aster flaccidus extract
Butea parviflora extract
Capsella bursa pastoris extract
Cavea tanguensis extract
Chrysosplenium nudicaule extract
Codonopsis bhutanica extract
Corydalis crispa extract
Corydalis dubia extract
flavonoid
Fraxinus paxiana extract
Gentiana urnula extract
Knema tenuinervia extract
Meconopsis simplicifolia extract
Myricarea rosea extract
Myrsine semiserrata extract
Otochilus lancitabius extract
Pedicularis integrifolia extract
Pedicularis longiflora extract
plant extract
Pleurospermum amabile extract
Polygonum macrophylla extract
Sapria himalayana extract
spasmolytic agent
unclassified drug
unindexed drug
Veronica cephaloides extract
abscess
Aconitum laciniatum
African trypanosomiasis
Ajania nubigena
Androsace strigillosa
animal cell
anthelmintic activity
antibacterial activity
antifungal activity
antimicrobial activity
antiprotozoal activity
article
ascites
Aster flaccidus
asthma
bark
benign tumor
Bhutan
bile duct disease
blood disease
bloodstream infection
bone disease
bone infection
Butea parviflora
capsella bursapastoris
Cavea tanguensis
chemosensitivity
chickenpox
Chrysosplenium nudicaule
Codonopsis bhutanica
common cold
Corydalis crispa
Corydalis dubia
coughing
cytotoxicity test
dehydration
diarrhea
drug activity
drug screening
dysentery
dyspepsia
edema
epistaxis
evaluation
eye disease
fever
flower
fracture
Fraxinus paxiana
gastritis
Gentiana urnula
gout
heart disease
hepatitis
hypertension
IC 50
infection
intoxication
kidney infection
Knema tenuinervia
leprosy
limb disease
liver disease
lung infection
malaria
Meconopsis simplicifolia
medical literature
medicinal plant
menstruation disorder
minimum inhibitory concentration
multidrug resistance
mumps
Myricarea rosea
Myrsine semiserrata
nephritis
neuralgia
nonhuman
Otochilus lancitabius
pancreas disease
paresthesia
Pedicularis integrifolia
Pedicularis longiflora
Phlogacanthus thyrsiformis
Phlogacanthus thyrsiformis extract
plant leaf
Pleurospermum amabile
polydipsia
Polygonum macrophylla
rheumatic disease
rhizome
Sapria himalayana
skin disease
skin tingling
stomach pain
traditional medicine
Trypanosoma brucei
tuberculosis
ulcer
urinary tract obstruction
Veronica cephaloides
wild type
wood
wound
Animals
Anti-Infective Agents
Antimalarials
Bhutan
Cell Line, Tumor
Cell Survival
Cercopithecus aethiops
Dose-Response Relationship, Drug
Ethnopharmacology
Formularies as Topic
Humans
Inhibitory Concentration 50
Medicine, Traditional
Microbial Sensitivity Tests
Pharmacopoeias as Topic
Plant Preparations
Plants, Medicinal
Trypanocidal Agents
Trypanosoma brucei rhodesiense
Vero Cells
Meconopsis simplicifolia
Trypanosoma brucei rhodesiense
วันที่เผยแพร่: 2011
บทคัดย่อ: Ethnopharmacological relevance: As many as 229 medicinal plants have been currently used in the Bhutanese Traditional Medicine (BTM) as a chief ingredient of polyherbal formulations and these plants have been individually indicated for treating various types of infections including malaria, tumor, and microbial. We have focused our study only on seven species of these plants. Aim of the study: We aim to evaluate the antiplasmodial, antimicrobial, anti-Trypanosoma brucei rhodesiense and cytotoxicity activities of the seven medicinal plants of Bhutan selected using an ethno-directed bio-rational approach. This study creates a scientific basis for their use in the BTM and gives foundation for further phytochemical and biological evaluations which can result in the discovery of new drug lead compounds. Materials and methods: A three stage process was conducted which consisted of: (1) an assessment of a pharmacopoeia and a formulary book of the BTM for their mode of plant uses; (2) selecting 25 anti-infective medicinal plants based on the five established criteria, collecting them, and screening for their major classes of phytochemicals using appropriate test protocols; and (3) finally analyzing the crude extracts of the seven medicinal plants, using the standard test protocols, for their antiplasmodial, antimicrobial, anti-Trypanosoma brucei rhodesiense and cytotoxicity activities as directed by the ethnopharmacological uses of each plant. Results: Out of 25 medicinal plants screened for their major classes of phytochemicals, the majority contained tannins, alkaloids and flavonoids. Out of the seven plant species investigated for their biological activities, all seven of them exhibited mild antimicrobial properties, five plants gave significant in vitro antiplasmodial activities, two plants gave moderate anti-Trypanosoma brucei rhodesiense activity, and one plant showed mild cytotoxicity. Meconopsis simplicifolia showed the highest antiplasmodial activity with IC 50 values of 0.40 μg/ml against TM4/8.2 strain (a wild type chloroquine and antifolate sensitive strain) and 6.39 μg/ml against K1CB1 (multidrug resistant strain) strain. Significantly the extracts from this plant did not show any cytotoxicity. Conclusions: These findings provide the scientific basis for the use of seven medicinal plants in the BTM for the treatment of malaria, microbial infections, infectious fevers, and the Trypanosoma brucei rhodesiense infection. The results also form a good preliminary basis for the prioritization of candidate plant species for further in-depth phytochemical and pharmacological investigations toward our quest to unearth lead antiparasitic, anticancer and antimicrobial compounds. © 2011 Elsevier Ireland Ltd All rights reserved.
URI: https://ir.swu.ac.th/jspui/handle/123456789/14478
https://www.scopus.com/inward/record.uri?eid=2-s2.0-80052032320&doi=10.1016%2fj.jep.2011.06.032&partnerID=40&md5=411884ccf029a556a5ce6e799fdba168
ISSN: 3788741
Appears in Collections:Scopus 1983-2021

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