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https://ir.swu.ac.th/jspui/handle/123456789/14476| Title: | Synthesis and structural characterization of 1-[2-(5-Nitro-1H-indol-2-yl) phenyl]methylpyridinium chloride |
| Authors: | Bremner J.B. Samosorn S. Skelton B.W. White A.H. |
| Keywords: | antiinfective agent bacterial protein indole derivative multidrug resistance protein NorA protein, Staphylococcus pyridinium derivative article chemistry conformation drug antagonism drug effect metabolism Staphylococcus aureus synthesis X ray crystallography Anti-Bacterial Agents Bacterial Proteins Crystallography Indoles Molecular Conformation Multidrug Resistance-Associated Proteins Pyridinium Compounds Staphylococcus aureus |
| Issue Date: | 2011 |
| Abstract: | In the course of studies on hybrid antibacterials incorporating 2-aryl-5-nitro-1Hindole moieties as potential bacterial NorA efflux pump inhibitors, the compound 1-[2-(5-nitro-1H-indol-2-yl)phenyl]methylpyridinium chloride (2) was synthesized and structurally characterized. This pyridinium chloride salt crystallized in the monoclinic space group P21/c with the following unit cell dimensions: a 10.274(3) Å, b 13.101(4) Å, c 13.439(4) Å, β 107.702(7)°, V 1723.2(9) Å 3, Z (f.u.) = 4; R1 = 0.048, and wR2 = 0.13. Of interest in the single crystal X-ray structure is the (intramolecular) disposition of the pyridinium plane over the indole heterocyclic residue [interplanar dihedral angle 17.91(4)°]. © 2011 by The Authors. |
| URI: | https://ir.swu.ac.th/jspui/handle/123456789/14476 https://www.scopus.com/inward/record.uri?eid=2-s2.0-80053280302&doi=10.3390%2fmolecules16097627&partnerID=40&md5=d2edd2dd5e107f5ccb61399edecf489a |
| ISSN: | 14203049 |
| Appears in Collections: | Scopus 1983-2021 |
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