Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14476
ชื่อเรื่อง: Synthesis and structural characterization of 1-[2-(5-Nitro-1H-indol-2-yl) phenyl]methylpyridinium chloride
ผู้แต่ง: Bremner J.B.
Samosorn S.
Skelton B.W.
White A.H.
Keywords: antiinfective agent
bacterial protein
indole derivative
multidrug resistance protein
NorA protein, Staphylococcus
pyridinium derivative
article
chemistry
conformation
drug antagonism
drug effect
metabolism
Staphylococcus aureus
synthesis
X ray crystallography
Anti-Bacterial Agents
Bacterial Proteins
Crystallography
Indoles
Molecular Conformation
Multidrug Resistance-Associated Proteins
Pyridinium Compounds
Staphylococcus aureus
วันที่เผยแพร่: 2011
บทคัดย่อ: In the course of studies on hybrid antibacterials incorporating 2-aryl-5-nitro-1Hindole moieties as potential bacterial NorA efflux pump inhibitors, the compound 1-[2-(5-nitro-1H-indol-2-yl)phenyl]methylpyridinium chloride (2) was synthesized and structurally characterized. This pyridinium chloride salt crystallized in the monoclinic space group P21/c with the following unit cell dimensions: a 10.274(3) Å, b 13.101(4) Å, c 13.439(4) Å, β 107.702(7)°, V 1723.2(9) Å 3, Z (f.u.) = 4; R1 = 0.048, and wR2 = 0.13. Of interest in the single crystal X-ray structure is the (intramolecular) disposition of the pyridinium plane over the indole heterocyclic residue [interplanar dihedral angle 17.91(4)°]. © 2011 by The Authors.
URI: https://ir.swu.ac.th/jspui/handle/123456789/14476
https://www.scopus.com/inward/record.uri?eid=2-s2.0-80053280302&doi=10.3390%2fmolecules16097627&partnerID=40&md5=d2edd2dd5e107f5ccb61399edecf489a
ISSN: 14203049
Appears in Collections:Scopus 1983-2021

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