Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14471
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dc.contributor.authorSilprasit K.
dc.contributor.authorSeetaha S.
dc.contributor.authorPongsanaraku P.
dc.contributor.authorHannongbua S.
dc.contributor.authorChoowongkomon K.
dc.date.accessioned2021-04-05T03:35:01Z-
dc.date.available2021-04-05T03:35:01Z-
dc.date.issued2011
dc.identifier.issn19960875
dc.identifier.other2-s2.0-81555216096
dc.identifier.urihttps://ir.swu.ac.th/jspui/handle/123456789/14471-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-81555216096&partnerID=40&md5=f478a90d9e8a4670e9a7d4443900f00d
dc.description.abstractNumerous herbal remedies against viral infections, including HIV-1, have been used as a part of Asian traditional medicine. However, the viral protein targets for inhibition by these medications are less well identified. HIV-1 reverse transcriptase is one of the targets, since high-efficiency inhibitors such as nonnucleoside HIV-1 reverse transcriptase inhibitor have been successfully used. In this work, hexane extracts of Asian medicinal plants were screened against HIV-1 reverse transcriptase. The results showed that the crude extracts from plants Cinnamomum loureiroi (stem bark), Quercus infectoria (fruit), Plumbago indica L. (root), Artocarpus heterophyllus Lam. (seed), Ocimum sanctum L. (leaves), Allium sativum L. (bulb) and Acorus calamus L. (rhizomes) showed strong HIV-1 reverse transcriptase inhibitory effects. The efficiency of anti-HIV-1RT activity was reported as 50% inhibitory concentrations (IC 50). This showed that the hexane crude extracts from A. calamus L. and A. heterophyllus Lam. contained potent activity against HIV-1 RT, with IC 50 of 32.96 ± 3.17 and 34.69 ± 2.41 μg/ml, respectively. © 2011 Academic Journals.
dc.subjectAcorus calamus extract
dc.subjectartocarpus heterophyllus extract
dc.subjectCinnamomum loureiroi extract
dc.subjectgarlic extract
dc.subjectOcimum tenuiflorum extract
dc.subjectplant extract
dc.subjectPlumbago indica extract
dc.subjectQuercus infectoria extract
dc.subjectRNA directed DNA polymerase
dc.subjectRNA directed DNA polymerase inhibitor
dc.subjectunclassified drug
dc.subjectarticle
dc.subjectArtocarpus heterophyllus
dc.subjectAsian
dc.subjectbark
dc.subjectCinnamomum loureiroi
dc.subjectcontrolled study
dc.subjectdrug effect
dc.subjectdrug efficacy
dc.subjectdrug mechanism
dc.subjectdrug potency
dc.subjectenzyme assay
dc.subjectenzyme inhibition
dc.subjectfluorescence analysis
dc.subjectfruit
dc.subjecthydrophobicity
dc.subjectIC 50
dc.subjectmedicinal plant
dc.subjectnonhuman
dc.subjectOcimum tenuiflorum
dc.subjectplant bulb
dc.subjectplant leaf
dc.subjectplant root
dc.subjectplant seed
dc.subjectplant stem
dc.subjectPlumbago indica
dc.subjectquercus infectoria
dc.subjectrhizome
dc.subjectAcorus calamus
dc.subjectAllium sativum
dc.subjectArtocarpus heterophyllus
dc.subjectCinnamomum
dc.subjectHuman immunodeficiency virus 1
dc.subjectOcimum tenuiflorum
dc.subjectPlumbago indica
dc.subjectQuercus infectoria
dc.titleAnti-HIV-1 reverse transcriptase activities of hexane extracts from some asian medicinal plants
dc.typeArticle
dc.rights.holderScopus
dc.identifier.bibliograpycitationJournal of Medicinal Plant Research. Vol 5, No.19 (2011), p.4899-4906
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