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DC Field | Value | Language |
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dc.contributor.author | Silprasit K. | |
dc.contributor.author | Seetaha S. | |
dc.contributor.author | Pongsanaraku P. | |
dc.contributor.author | Hannongbua S. | |
dc.contributor.author | Choowongkomon K. | |
dc.date.accessioned | 2021-04-05T03:35:01Z | - |
dc.date.available | 2021-04-05T03:35:01Z | - |
dc.date.issued | 2011 | |
dc.identifier.issn | 19960875 | |
dc.identifier.other | 2-s2.0-81555216096 | |
dc.identifier.uri | https://ir.swu.ac.th/jspui/handle/123456789/14471 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-81555216096&partnerID=40&md5=f478a90d9e8a4670e9a7d4443900f00d | |
dc.description.abstract | Numerous herbal remedies against viral infections, including HIV-1, have been used as a part of Asian traditional medicine. However, the viral protein targets for inhibition by these medications are less well identified. HIV-1 reverse transcriptase is one of the targets, since high-efficiency inhibitors such as nonnucleoside HIV-1 reverse transcriptase inhibitor have been successfully used. In this work, hexane extracts of Asian medicinal plants were screened against HIV-1 reverse transcriptase. The results showed that the crude extracts from plants Cinnamomum loureiroi (stem bark), Quercus infectoria (fruit), Plumbago indica L. (root), Artocarpus heterophyllus Lam. (seed), Ocimum sanctum L. (leaves), Allium sativum L. (bulb) and Acorus calamus L. (rhizomes) showed strong HIV-1 reverse transcriptase inhibitory effects. The efficiency of anti-HIV-1RT activity was reported as 50% inhibitory concentrations (IC 50). This showed that the hexane crude extracts from A. calamus L. and A. heterophyllus Lam. contained potent activity against HIV-1 RT, with IC 50 of 32.96 ± 3.17 and 34.69 ± 2.41 μg/ml, respectively. © 2011 Academic Journals. | |
dc.subject | Acorus calamus extract | |
dc.subject | artocarpus heterophyllus extract | |
dc.subject | Cinnamomum loureiroi extract | |
dc.subject | garlic extract | |
dc.subject | Ocimum tenuiflorum extract | |
dc.subject | plant extract | |
dc.subject | Plumbago indica extract | |
dc.subject | Quercus infectoria extract | |
dc.subject | RNA directed DNA polymerase | |
dc.subject | RNA directed DNA polymerase inhibitor | |
dc.subject | unclassified drug | |
dc.subject | article | |
dc.subject | Artocarpus heterophyllus | |
dc.subject | Asian | |
dc.subject | bark | |
dc.subject | Cinnamomum loureiroi | |
dc.subject | controlled study | |
dc.subject | drug effect | |
dc.subject | drug efficacy | |
dc.subject | drug mechanism | |
dc.subject | drug potency | |
dc.subject | enzyme assay | |
dc.subject | enzyme inhibition | |
dc.subject | fluorescence analysis | |
dc.subject | fruit | |
dc.subject | hydrophobicity | |
dc.subject | IC 50 | |
dc.subject | medicinal plant | |
dc.subject | nonhuman | |
dc.subject | Ocimum tenuiflorum | |
dc.subject | plant bulb | |
dc.subject | plant leaf | |
dc.subject | plant root | |
dc.subject | plant seed | |
dc.subject | plant stem | |
dc.subject | Plumbago indica | |
dc.subject | quercus infectoria | |
dc.subject | rhizome | |
dc.subject | Acorus calamus | |
dc.subject | Allium sativum | |
dc.subject | Artocarpus heterophyllus | |
dc.subject | Cinnamomum | |
dc.subject | Human immunodeficiency virus 1 | |
dc.subject | Ocimum tenuiflorum | |
dc.subject | Plumbago indica | |
dc.subject | Quercus infectoria | |
dc.title | Anti-HIV-1 reverse transcriptase activities of hexane extracts from some asian medicinal plants | |
dc.type | Article | |
dc.rights.holder | Scopus | |
dc.identifier.bibliograpycitation | Journal of Medicinal Plant Research. Vol 5, No.19 (2011), p.4899-4906 | |
Appears in Collections: | Scopus 1983-2021 |
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