Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14471
ชื่อเรื่อง: Anti-HIV-1 reverse transcriptase activities of hexane extracts from some asian medicinal plants
ผู้แต่ง: Silprasit K.
Seetaha S.
Pongsanaraku P.
Hannongbua S.
Choowongkomon K.
Keywords: Acorus calamus extract
artocarpus heterophyllus extract
Cinnamomum loureiroi extract
garlic extract
Ocimum tenuiflorum extract
plant extract
Plumbago indica extract
Quercus infectoria extract
RNA directed DNA polymerase
RNA directed DNA polymerase inhibitor
unclassified drug
article
Artocarpus heterophyllus
Asian
bark
Cinnamomum loureiroi
controlled study
drug effect
drug efficacy
drug mechanism
drug potency
enzyme assay
enzyme inhibition
fluorescence analysis
fruit
hydrophobicity
IC 50
medicinal plant
nonhuman
Ocimum tenuiflorum
plant bulb
plant leaf
plant root
plant seed
plant stem
Plumbago indica
quercus infectoria
rhizome
Acorus calamus
Allium sativum
Artocarpus heterophyllus
Cinnamomum
Human immunodeficiency virus 1
Ocimum tenuiflorum
Plumbago indica
Quercus infectoria
วันที่เผยแพร่: 2011
บทคัดย่อ: Numerous herbal remedies against viral infections, including HIV-1, have been used as a part of Asian traditional medicine. However, the viral protein targets for inhibition by these medications are less well identified. HIV-1 reverse transcriptase is one of the targets, since high-efficiency inhibitors such as nonnucleoside HIV-1 reverse transcriptase inhibitor have been successfully used. In this work, hexane extracts of Asian medicinal plants were screened against HIV-1 reverse transcriptase. The results showed that the crude extracts from plants Cinnamomum loureiroi (stem bark), Quercus infectoria (fruit), Plumbago indica L. (root), Artocarpus heterophyllus Lam. (seed), Ocimum sanctum L. (leaves), Allium sativum L. (bulb) and Acorus calamus L. (rhizomes) showed strong HIV-1 reverse transcriptase inhibitory effects. The efficiency of anti-HIV-1RT activity was reported as 50% inhibitory concentrations (IC 50). This showed that the hexane crude extracts from A. calamus L. and A. heterophyllus Lam. contained potent activity against HIV-1 RT, with IC 50 of 32.96 ± 3.17 and 34.69 ± 2.41 μg/ml, respectively. © 2011 Academic Journals.
URI: https://ir.swu.ac.th/jspui/handle/123456789/14471
https://www.scopus.com/inward/record.uri?eid=2-s2.0-81555216096&partnerID=40&md5=f478a90d9e8a4670e9a7d4443900f00d
ISSN: 19960875
Appears in Collections:Scopus 1983-2021

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