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https://ir.swu.ac.th/jspui/handle/123456789/14402| ชื่อเรื่อง: | Sox9 is upstream of microRNA-140 in cartilage |
| ผู้แต่ง: | Nakamura Y. He X. Kato H. Wakitani S. Kobayashi T. Watanabe S. Iida A. Tahara H. Warman M.L. Watanapokasin R. Postlethwait J.H. |
| Keywords: | In situ hybridization MicroRNA-140 (miR-140) RT-PCR siRNA Sox9 T/C-28 Zebrafish Mammals Polymerase chain reaction RNA Tissue Cartilage microRNA microRNA 140 mutant protein platelet derived growth factor alpha receptor small interfering RNA transcription factor Sox9 unclassified drug animal experiment article cartilage cartilage cell controlled study human human cell in situ hybridization nonhuman protein expression reverse transcription polymerase chain reaction transcription regulation zebra fish Animals Binding Sites Cartilage Chondrocytes Chondrogenesis Embryonic Development Gene Expression Regulation, Developmental Humans In Situ Hybridization MicroRNAs Phylogeny Protein Binding RNA, Small Interfering SOX9 Transcription Factor Ubiquitin-Protein Ligases Zebrafish Danio rerio Mammalia |
| วันที่เผยแพร่: | 2012 |
| บทคัดย่อ: | MicroRNA-140 (miR-140) is specifically expressed in developing cartilage tissues. We have previously reported that miR-140 plays an important role during palatal cartilage development by modulating platelet-derived growth factor receptor alpha (pdgfra) in zebrafish. However, the regulatory mechanism of miR-140 in cartilage is still unknown. Using developing zebrafish, sox9a mutant (sox9a-/-) and sox9b mutant (sox9b-/-) zebrafish and SOX9 small interfering RNA in human chondrocytes, T/C-28 cells, we found that miR-140 is regulated by the cartilage master transcription regulator Sox9 in zebrafish and mammalian cells. © 2011 Springer Science+Business Media, LLC. |
| URI: | https://ir.swu.ac.th/jspui/handle/123456789/14402 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84856260583&doi=10.1007%2fs12010-011-9404-y&partnerID=40&md5=b7c62c3c83efc0cb97c7912a0ba81b75 |
| ISSN: | 2732289 |
| Appears in Collections: | Scopus 1983-2021 |
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