Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14377
ชื่อเรื่อง: Reduction of atherogenic risk in patients with type 2 diabetes by curcuminoid extract: A randomized controlled trial
ผู้แต่ง: Chuengsamarn S.
Rattanamongkolgul S.
Phonrat B.
Tungtrongchitr R.
Jirawatnotai S.
Keywords: adiponectin
alanine aminotransferase
curcumin
glucose
hemoglobin A1c
high density lipoprotein cholesterol
leptin
low density lipoprotein cholesterol
triacylglycerol
uric acid
abdominal obesity
adult
article
atherosclerosis
body fat
body mass
body weight
cardiovascular risk
cholesterol blood level
comparative study
constipation
controlled study
diabetic patient
double blind procedure
drug efficacy
drug safety
fasting plasma glucose
female
follow up
glucose blood level
hot flush
human
insulin resistance
intraabdominal fat
major clinical study
male
metabolic parameters
middle aged
nausea
non insulin dependent diabetes mellitus
parallel design
protein blood level
pruritus
pulse wave
randomized controlled trial
vertigo
waist circumference
Abdominal obesity (visceral fat and total body fat)
Atherogenic risk
Curcuminoid extract
Insulin resistance
Pulse wave velocity (PWV)
Type 2 diabetes
Atherosclerosis
Curcumin
Diabetes Mellitus, Type 2
Double-Blind Method
Female
Humans
Male
Middle Aged
Patient Compliance
Placebos
วันที่เผยแพร่: 2014
บทคัดย่อ: Curcumin is a phytocompound found in the root of turmeric, a common herbal ingredient in many Asian cuisines. The compound contains anti-inflammatory activity, which is mediated through an up-regulation of adiponectin and reduction of leptin. Consumption of curcumin was shown to prevent some deteriorative conditions caused by inflammation, such as ulcerative colitis, rheumatoid arthritis and esophagitis, and so on. Inflammation-associated cardiovascular conditions such as atherosclerosis are common in diabetes patients. The anti-inflammation effect of curcumin might be beneficial to prevent such condition in these patients. We aim to evaluate an antiatherosclerosis effect of curcumin in diabetes patients. Effects of curcumin on risk factors for atherosclerosis were investigated in a 6-month randomized, double-blinded and placebo-controlled clinical trial that included subjects diagnosed with type 2 diabetes. An atherosclerosis parameter, the pulse wave velocity, and other metabolic parameters in patients treated with placebo and curcumin were compared. Our results showed that curcumin intervention significantly reduced pulse wave velocity, increased level of serum adiponectin and decreased level of leptin. These results are associated with reduced levels of homeostasis model assessment-insulin resistance, triglyceride, uric acid, visceral fat and total body fat. In summary, a 6-month curcumin intervention in type 2 diabetic population lowered the atherogenic risks. In addition, the extract helped to improve relevant metabolic profiles in this high-risk population. © 2014 Elsevier Inc.
URI: https://ir.swu.ac.th/jspui/handle/123456789/14377
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84892527914&doi=10.1016%2fj.jnutbio.2013.09.013&partnerID=40&md5=e54b5e4e2ac16fb7a65572ef74477455
ISSN: 9552863
Appears in Collections:Scopus 1983-2021

Files in This Item:
There are no files associated with this item.


Items in SWU repository are protected by copyright, with all rights reserved, unless otherwise indicated.