Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14372
ชื่อเรื่อง: Microtextured surfaces for deep-brain stimulation electrodes: A biologically inspired design to reduce lead migration
ผู้แต่ง: Parittotokkaporn T.
Thomas D.G.T.
Schneider A.
Huq E.
Davies B.L.
Degenaar P.
Rodriguez Y Baena F.
Keywords: lead
animal tissue
biosensor
body position
brain depth stimulation
brain tissue
cadaver
electrode
ex vivo study
fiber optics
gravity
medical instrumentation
migration
nonhuman
review
skull
supine position
swine
tissue injury
Algorithms
Animals
Brain
Cadaver
Deep Brain Stimulation
Device Removal
Electrodes, Implanted
Equipment Design
External Fixators
Foreign-Body Migration
Friction
Posture
Swine
วันที่เผยแพร่: 2012
บทคัดย่อ: Objective: Hardware-related complications of deep brain stimulation (DBS) surgery have been reported with adverse effects in postoperative electrode migration. We report that the addition of microtextured features to the surface of a DBS-like probe can minimize the extent of electrode migration in ex vivo porcine brain. Methods: A DBS lead and microtextured strips, mounted with a fiberoptic displacement sensor, were embedded 15-mm deep inside a cadaveric porcine brain through holes on the skull. The local displacement of brain tissue surrounding each strip was detected along the direction of insertion by the optical sensor while the porcine head simulated brain shift during rotation between supine and upright postures. Results: The triangular toothed strip with protruding height of 250 μm enabled a better grip of the surrounding brain tissue than standard DBS lead, minimizing local brain displacement to 77 μm versus 326 μm respectively, when the porcine head was shifted from the supine to the upright position as the result of gravity. In addition, brain tissue damage resulting from the removal of toothed strips exhibited less-extensive tissue disruption, attributable to the microtextured surface. Conclusions: These preliminary results show that microtextured strips embedded into cadaveric porcine brain produce an anchoring effect on local tissue during brain shift, suggesting a way to reduce DBS lead migration without additional tissue damage beyond the strip geometry. © 2012 Elsevier Inc. All rights reserved.
URI: https://ir.swu.ac.th/jspui/handle/123456789/14372
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84863410107&doi=10.1016%2fj.wneu.2011.06.040&partnerID=40&md5=62800ca4bfeb3dcc2fbfd4c3f74d5e8f
ISSN: 18788750
Appears in Collections:Scopus 1983-2021

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