Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14361
ชื่อเรื่อง: Xanthones in mangosteen juice are absorbed and partially conjugated by healthy adults
ผู้แต่ง: Chitchumroonchokchai C.
Riedl K.M.
Suksumrarn S.
Clinton S.K.
Kinghorn A.D.
Failla M.L.
Keywords: alpha mangostin
unclassified drug
xanthone derivative
glucuronide
mangostin
sulfate
xanthone derivative
area under the curve
article
digestion
drug bioavailability
female
fruit juice
Garcinia mangostana
human
human experiment
lipid diet
male
maximum plasma concentration
meal
micelle
nonhuman
normal human
pericarp
serum
time to maximum plasma concentration
urinalysis
adult
beverage
blood
chemistry
clinical trial
comparative study
electrospray mass spectrometry
fruit
high performance liquid chromatography
intestine absorption
kinetics
limit of detection
metabolism
United States
urine
Garcinia mangostana
Adult
Beverages
Chromatography, High Pressure Liquid
Digestion
Female
Fruit
Garcinia mangostana
Glucuronides
Humans
Intestinal Absorption
Kinetics
Limit of Detection
Male
Micelles
Ohio
Spectrometry, Mass, Electrospray Ionization
Sulfates
Xanthones
วันที่เผยแพร่: 2012
บทคัดย่อ: The proposed health-promoting effects of the pericarp from mangosteen fruit have been attributed to a family of polyphenols referred to as xanthones. The purpose of this study was to determine the bioavailability of xanthones from 100% mangosteen juice in healthy adult participants (n = 10). Pericarp particles accounted for 1% of the mass and 99% of the xanthone concentration in the juice. The juice provided 5.3 ± 0.1 mmol/L total xanthones with α-mangostin, garcinones (C, D, and E), γ-mangostin, gartanins, and other identified xanthones accounting for 58, 2, 6, 4, and 5%, respectively. Participants ingested 60 mL mangosteen juice with a high-fat breakfast. Free and conjugated (glucuronidated/sulfated) xanthones were detected in serum and urine. There was marked variation in the AUC (762- 4030 nmol/L × h), maximum concentration (113 ± 107 nmol/L), and time to maximum concentration (3.7 ± 2.4 h) for a-mangostin in sera during the 24-h collection. Similarly, xanthones in 24-h urine ranged from 0.9 to 11.1 mmol and accounted for 2.0 ± 0.3% (range 0.3-3.4%) of the ingested dose. There were no significant differences between female and male participants in mean pharmacokinetic values of α-mangostin in serum and urinary xanthones. Only 15.4 ± 0.7% of total xanthones in pericarp particles in the juice partitioned into mixed micelles during in vitro digestion. These results show that xanthones in mangosteen juice are absorbed when ingested along with a high-fat meal, although release of xanthones from pericarp particles during digestion may be limited. © 2012 American Society for Nutrition.
URI: https://ir.swu.ac.th/jspui/handle/123456789/14361
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84861142005&doi=10.3945%2fjn.111.156992&partnerID=40&md5=2c5ee8159becf2708c3c06ebab6e4631
ISSN: 223166
Appears in Collections:Scopus 1983-2021

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