Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14331
ชื่อเรื่อง: Inostamycin enhanced TRAIL-induced apoptosis through DR5 upregulation on the cell surface
ผู้แต่ง: Yamamoto K.
Makino M.
Watanapokasin R.
Tashiro E.
Imoto M.
Keywords: caspase
death receptor 4
death receptor 5
inostamycin
small interfering RNA
tumor necrosis factor related apoptosis inducing ligand
apoptosis
article
cancer cell
cell surface
colorectal cancer
controlled study
drug potentiation
human
human cell
priority journal
upregulation
Antineoplastic Combined Chemotherapy Protocols
Apoptosis
Blotting, Western
Cell Survival
Colorectal Neoplasms
Drug Synergism
Flow Cytometry
Furans
Gene Expression Regulation, Neoplastic
HCT116 Cells
Humans
Real-Time Polymerase Chain Reaction
Receptors, TNF-Related Apoptosis-Inducing Ligand
RNA, Neoplasm
RNA, Small Interfering
TNF-Related Apoptosis-Inducing Ligand
Up-Regulation
วันที่เผยแพร่: 2012
บทคัดย่อ: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been considered as a possible therapeutic agent for cancer treatment. This is because of its selective cytotoxicity against various cancer cells without a detrimental effect on normal cells. However, recent studies have reported that the potential application of TRAIL in cancer therapy is limited, as many cancer cells have been found to be resistant to TRAIL. Therefore, small molecule compounds that potentiate the cytotoxicity of TRAIL would be strategic candidates for therapeutic applications in combination with TRAIL. Here we found that a combined treatment of inostamycin and TRAIL synergistically induced caspase-dependent apoptosis in HCT116 cells. Inostamycin upregulated DR5, and a knockdown of DR5 suppressed the apoptosis that was synergistically induced by co-treatment with inostamycin and TRAIL. Moreover, inostamycin increased the expression of DR5 on the cell surface. Therefore, inostamycin-increased cell surface expression of DR5 may have contributed to the enhancement of TRAIL-induced apoptosis. Our study suggests that combined treatment with inostamycin and TRAIL may offer a strategy to overcome TRAIL resistance in tumor cells. © 2012 Japan Antibiotics Research Association All rights reserved.
URI: https://ir.swu.ac.th/jspui/handle/123456789/14331
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84863332135&doi=10.1038%2fja.2012.21&partnerID=40&md5=1b1a155cd27086df346619182a2e9b92
ISSN: 218820
Appears in Collections:Scopus 1983-2021

Files in This Item:
There are no files associated with this item.


Items in SWU repository are protected by copyright, with all rights reserved, unless otherwise indicated.