Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14277
ชื่อเรื่อง: Enhancement of TNF-α induced antiproliferation in human cervical cancer cells by extracts from Thai medicinal plants
ผู้แต่ง: Managit C.
Sithisarn P.
Jarikasem S.
Sakurai H.
Saiki I.
วันที่เผยแพร่: 2014
บทคัดย่อ: Human cervical cancer is known to be a dreadful disease with high resistance to chemotherapeutic drugs in clinical use. Natural products are valuable sources for development of anticancer agents. Many plant-derived anticancer compounds were reported to modulate signal transduction pathway associated with cell proliferation and apoptosis. One well-known pathway is via the enhancement of TNF-α, a cytokine that can induce apoptotic cell death and inhibit tumorigenesis. The purpose of this study is to evaluate TNF-α antiproliferative synergistic activity of Thai medicinal plant extracts. The antiproliferative effects were determined in human cervical cancer (HeLa) cells using WST-1 cell proliferating assay. Among twenty six different tested extracts at the concentration of 30 μg ml-1, 95% ethanolic extract from stems of Derris scandens, aqueous extract from leaves of Azadirachta indica, aqueous extract from leaves of A. indica var. siamensis and 95% ethanolic extract from roots of Amomum biflorum significantly decreased viability of HeLa cells treated with TNF-α (20 ng/ml). However, only 95% ethanolic extract from roots of A. biflorum combined with TNF-α significantly decreased viability of HeLa cells to 70.96±2.25% cell viability, when compared to cell viability of HeLa cells treated with only plant extract (93.84±10.73%). Data suggested that this plant extract enhanced TNF-α antiproliferative activity in HeLa cells and it has potential for further development as chemotherapeutic agent for anticancer therapy via the enhancement of TNF-α induced apoptosis of cancer cells. © ISHS.
URI: https://ir.swu.ac.th/jspui/handle/123456789/14277
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899560993&doi=10.17660%2factahortic.2014.1023.28&partnerID=40&md5=df68560ce6f8b6296010a669639bd1a1
ISSN: 5677572
Appears in Collections:Scopus 1983-2021

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