Please use this identifier to cite or link to this item: https://ir.swu.ac.th/jspui/handle/123456789/14265
ชื่อเรื่อง: Antiproliferative effect of α-mangostin on canine osteosarcoma cells
ผู้แต่ง: Krajarng A.
Nilwarankoon S.
Suksamrarn S.
Watanapokasin R.
Keywords: alpha mangostin
antineoplastic agent
DNA
hoe 33342
phosphatidylserine
unclassified drug
xanthone derivative
animal cell
antiproliferative activity
apoptosis
article
cell cycle G1 phase
cell membrane
cell nucleus fragmentation
cell strain D 17
cellular parameters
concentration response
controlled study
DNA fragmentation
dog
drug cytotoxicity
drug isolation
flow cytometry
Garcinia mangostana
gel electrophoresis
IC 50
mitochondrial membrane potential
nonhuman
nuclear condensation
nucleosome
osteosarcoma
osteosarcoma cell
pericarp
phospholipid metabolism
staining
Animals
Antineoplastic Agents, Phytogenic
Cell Cycle
Cell Line, Tumor
Cell Proliferation
Cell Survival
Dogs
Garcinia mangostana
Osteosarcoma
Xanthones
Canis familiaris
Garcinia mangostana
วันที่เผยแพร่: 2012
บทคัดย่อ: Osteosarcoma is the most frequently diagnosed primary bone tumor in dog. Since chemotherapeutics are quite limited due to high cost and severe toxicity, therefore, the ultimate goal is to discover cost-effective therapeutics with less toxicity. We have studied the effect of α-mangostin, a xanthone derivative isolated from pericarp of mangosteen (Garcinia mangostana Linn.) in canine osteosarcoma, D-17 cells. The results showed that α-mangostin induced antiproliferation with IC50 at 15μg/ml. Hoechst 33342 nuclear staining and nucleosomal DNA-gel electrophoresis revealed that α-mangostin could induce nuclear condensation and fragmentation, typically seen in apoptosis. Cell cycle analysis demonstrated that α-mangostin induced sub-G1 peak. In addition, α-mangostin also induced membrane flipping of the phosphatidylserine and the loss of mitochondrial membrane potential in D-17 cells. In conclusion, α-mangostin, induced apoptotic cell death against canine osteosarcoma D-17 cells, could be a potential candidate for preventive and therapeutic application for bone cancer treatment in dogs. © 2012 Elsevier Ltd.
URI: https://ir.swu.ac.th/jspui/handle/123456789/14265
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84863108518&doi=10.1016%2fj.rvsc.2012.01.015&partnerID=40&md5=5ce11b57663ec1f4cc4b389c5adeb1ce
ISSN: 345288
Appears in Collections:Scopus 1983-2021

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